Browsing by Author "Gkretsi, V."
Now showing items 1-12 of 12
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Article
Cell adhesion and matrix stiffness: Coordinating cancer cell invasion and metastasis
Gkretsi, V.; Stylianopoulos, T. (2018)Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's adhesome at cell-ECM adhesion sites and ...
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Conference Object
Double-hydrophilic semi-interpenetrating hydrogels with tunable and predictable mechanical performance
Papaparaskeva, G,; Voutouri, C.; Gkretsi, V.; Achilleos, M.; Safarik, I.; Pospiskova, K.; Stylianopoulos, T.; Krasia‐Christoforou, Theodora (2018)
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Article
Exploring the nano-surface of collagenous and other fibrotic tissues with AFM
Stylianou, A.; Gkretsi, V.; Patrickios, Costas S.; Stylianopoulos, Triantafyllos (2017)Atomic force microscope (AFM) is a powerful and invaluable tool for imaging and probing the mechanical properties of biological samples at the nanometric scale. The importance of nano-scale characterization and nanomechanics ...
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Article
Exploring the nano-surface of collagenous and other fibrotic tissues with AFM
Stylianou, A.; Gkretsi, V.; Patrickios, C. S.; Stylianopoulos, T. (2017)Atomic force microscope (AFM) is a powerful and invaluable tool for imaging and probing the mechanical properties of biological samples at the nanometric scale. The importance of nano-scale characterization and nanomechanics ...
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Article
Hyaluronan-Derived Swelling of Solid Tumors, the Contribution of Collagen and Cancer Cells, and Implications for Cancer Therapy
Voutouri, C.; Polydorou, C.; Papageorgis, P.; Gkretsi, V.; Stylianopoulos, T. (2016)Despite the important role that mechanical forces play in tumor growth and therapy, the contribution of swelling to tumor mechanopathology remains unexplored. Tumors rich in hyaluronan exhibit a highly negative fixed charge ...
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Identification of Ras suppressor-1 (RSU-1) as a potential breast cancer metastasis biomarker using a three-dimensional in vitro approach
Gkretsi, V.; Stylianou, A.; Louca, M.; Stylianopoulos, T. (2017)Breast cancer (BC) is the most common malignant disease in women, with most patients dying from metastasis to distant organs, making discovery of novel metastasis biomarkers and therapeutic targets imperative. Extracellular ...
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Article
Remodeling components of the tumor microenvironment to enhance cancer therapy
Gkretsi, V.; Stylianou, A.; Papageorgis, P.; Polydorou, C.; Stylianopoulos, T. (2015)Solid tumor pathophysiology is characterized by an abnormal microenvironment that guides tumor progression and poses barriers to the efficacy of cancer therapies. Most common among tumor types are abnormalities in the ...
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Article
Screening for Familial Mediterranean Fever M694V and V726A mutations in the Greek population.
Gkretsi, V.; Constantinou-Deltas, Constantinos D.; Yapijakis, C.; Lamnissou, Klea (2009)Familial Mediterranean Fever (FMF) is an autosomal recessive genetic disease that primarily affects populations surrounding the Mediterranean basin. FMF patients suffer from recurrent episodes of fever accompanied by ...
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Article
Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration
Kalli, M.; Papageorgis, P.; Gkretsi, V.; Stylianopoulos, T. (2018)Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated ...
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Article
Targeting Inflammation to Improve Tumor Drug Delivery
Gkretsi, V.; Zacharia, L. C.; Stylianopoulos, T. (2017)Inefficient delivery of drugs is a main cause of chemotherapy failure in hypoperfused tumors. To enhance perfusion and drug delivery in these tumors, two strategies have been developed: vascular normalization, aiming at ...
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Article
Transforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion
Stylianou, A.; Gkretsi, V.; Stylianopoulos, T. (2018)Background: Tumor microenvironment consists of the extracellular matrix (ECM), stromal cells, such as fibroblasts (FBs) and cancer associated fibroblasts (CAFs), and a myriad of soluble factors. In many tumor types, including ...
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Article
Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPA)
Gkretsi, V.; Stylianou, A.; Stylianopoulos, T. (2017)A hallmark of cancer cells is their ability to invade surrounding tissues and form metastases. Cell-extracellular matrix (ECM)-adhesion proteins are crucial in metastasis, connecting tumor ECM with actin cytoskeleton thus ...