Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Title
Now showing items 24-43 of 677
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Analysis of binding parameters of HIV-1 integrase inhibitors: Correlates of drug inhibition and resistance
(2009)This study undertook an exploratory data analysis of the binding parameters of HIV-1 integrase inhibitors. The study group involved inhibitors in preclinical development from the diketo acid, pyrroloquinoline and naphthyridine ...
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Annual cycle of mesozooplankton at the coastal waters of Cyprus (Eastern Levantine basin)
(Oxford Academic, 2023-01-20)This study is the first to explore monthly and seasonal succession of the zooplankton community in coastal waters of Cyprus using a 12-month period time series. A total of 192 taxa of mesozooplankton (MZ), 145 of which ...
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Application of topoisomerase assays in the evaluation of natural products as antitumor agents
(1999)Initially, DNA topoisomerase (topo) inhibitors found clinical applications as antibiotics and cancer chemotherapeutic agents. Recently, we demonstrated that plant flavonoids that inhibit mammalian topo I or topo II might ...
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Architectural insight into inovirus-associated vectors (IAVs) and development of IAV-based vaccines inducing humoral and cellular responses: Implications in HIV-1 vaccines
(2014)Inovirus-associated vectors (IAVs) are engineered, non-lytic, filamentous bacteriophages that are assembled primarily from thousands of copies of the major coat protein gp8 and just five copies of each of the four minor ...
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Are all islands the same? A comparative thermoregulatory approach in four insular populations
(Brill, 2022-12-21)As ectotherms, lizards, among the best models in thermal studies, are influenced by many abiotic factors. Interestingly, there is a scarcity of data regarding the impact that insularity may have on thermoregulation. Islands, ...
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Are terrestrial isopods able to use stridulation and vibrational communication as forms of intra and interspecific signaling and defense strategies as insects do? A preliminary study in Armadillo officinalis
(2019)The capability of producing sounds and vibrations is well known in insects and is thought to be a form of intra- and interspecific communication. Sounds and vibrations are used and modulated for several aims such as ...
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Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
(2007)Modifications on histones control important biological processes through their effects on chromatin structure. Methylation at lysine 4 on histone H3 (H3K4) is found at the 5′ end of active genes and contributes to ...
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Review
As natural as it gets
(eScholarship, 2017)
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Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIα
(1998)Topoisomerase II (topo II), an essential enzyme for cell viability, is also the target for clinically important anti-neoplastic agents that stimulate topo II-mediated DNA scission. The role of alterations in topo IIα ...
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Authors' reply
(2010)
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Automated scientific assistant for Cancer and Chemoprevention
(2013)Logical modeling of cell biological phenomena has the potential to facilitate both the understanding of the mechanisms that underly the phenomena as well as the process of experimentation undertaken by the biologist. ...
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Automated species recognition of antbirds in a Mexican rainforest using hidden Markov models
(2008)Behavioral and ecological studies would benefit from the ability to automatically identify species from acoustic recordings. The work presented in this article explores the ability of hidden Markov models to distinguish ...
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Autosomal dominant medullary cystic kidney disease: Evidence of gene locus heterogeneity
(1998)Autosomal dominant medullary cystic kidney disease (ADMCKD
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Autosomal dominant polycystic kidney disease - Type 2. Ultrasound, genetic and clinical correlations
(2000)Background. Ultrasound, genetic and clinical correlations are available for ADPKD-1, but lacking for ADPKD-2. The present study was carried out to address: (i) the age-related diagnostic usefulness of ultrasound compared ...
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Autosomal dominant polycystic kidney disease: Molecular genetics and molecular pathogenesis
(2000)Mutations in three different genes, PKD1, PKD2 and PKD3, can cause a very similar clinical picture of the autosomal dominant form of polycystic kidney disease (ADPKD). Apparently, mutations in the PKD3 gene, which is still ...
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Autosomal dominant tubulointerstitial kidney disease: Diagnosis, classification, and management - A KDIGO consensus report
(2015)Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN), and mucin-1 (MUC1). Multiple names have been ...