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Donor-derived breast cancer in a bone marrow transplantation recipient

dc.contributor.authorGolfinopoulos, Vassilisen
dc.contributor.authorPentheroudakis, Georgeen
dc.contributor.authorKamakari, S.en
dc.contributor.authorMetaxa-Mariatou, V.en
dc.contributor.authorPavlidis, Nicholasen
dc.creatorGolfinopoulos, Vassilisen
dc.creatorPentheroudakis, Georgeen
dc.creatorKamakari, S.en
dc.creatorMetaxa-Mariatou, V.en
dc.creatorPavlidis, Nicholasen
dc.date.accessioned2018-06-22T09:53:14Z
dc.date.available2018-06-22T09:53:14Z
dc.date.issued2009
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41733
dc.description.abstractWe present the case of a young lady who had been treated for acute myelocytic leukemia at the age of 14 by means of allogeneic bone marrow transplantation, the donor being her sister. At the age of 28 she underwent modified radical mastectomy for invasive breast adenocarcinoma. Genetic analysis revealed chimeric cellular populations on both the tumour and normal tissues of the patient with preponderance of donor-derived cells. We conclude that the patient's epithelia had been repopulated by donor-derived hemopoietic stem cells which gave rise to a malignant mammary neoplasm several years later. The donor remains healthy to date. This case adds weight to the theory of pluripotent normal and neoplastic stem cell histogenesis and emphasizes the pivotal role of supporting host stroma in carcinogenesis. © 2008 Springer Science+Business Media, LLC.en
dc.language.isoengen
dc.sourceBreast cancer research and treatmenten
dc.subjectArticleen
dc.subjectCyclophosphamideen
dc.subjectCytarabineen
dc.subjectHumanen
dc.subjectAdenocarcinomaen
dc.subjectHumansen
dc.subjectTransplantationen
dc.subjectAdulten
dc.subjectBreast neoplasmsen
dc.subjectFemaleen
dc.subjectNeoplasmen
dc.subjectPriority journalen
dc.subjectMetastasisen
dc.subjectNeoplasticen
dc.subjectAcute granulocytic leukemiaen
dc.subjectIdarubicinen
dc.subjectImmunohistochemistryen
dc.subjectLymphatic metastasisen
dc.subjectBreast canceren
dc.subjectCase reporten
dc.subjectHistopathologyen
dc.subjectMastectomyen
dc.subjectCancer regressionen
dc.subjectWhole body radiationen
dc.subjectGraft recipienten
dc.subjectDnaen
dc.subjectAdolescenten
dc.subjectEpidermal growth factor receptor 2en
dc.subjectGenetic analysisen
dc.subjectAcute diseaseen
dc.subjectAlemtuzumaben
dc.subjectAllogenic bone marrow transplantationen
dc.subjectBone marrow examinationen
dc.subjectBone marrow transplantationen
dc.subjectBreast adenocarcinomaen
dc.subjectBreast carcinogenesisen
dc.subjectBreast epitheliumen
dc.subjectCell differentiationen
dc.subjectCell transformationen
dc.subjectChimeraen
dc.subjectDonoren
dc.subjectEchomammographyen
dc.subjectEpithelial cellsen
dc.subjectHematopoietic stem cellen
dc.subjectHematopoietic stem cellsen
dc.subjectHomologousen
dc.subjectLeukemiaen
dc.subjectLiving donorsen
dc.subjectMyeloiden
dc.subjectNeoplastic stem cellsen
dc.subjectPluripotent stem cellsen
dc.subjectShort tandem repeaten
dc.subjectStromal cellsen
dc.subjectTransplantation conditioningen
dc.titleDonor-derived breast cancer in a bone marrow transplantation recipienten
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1007/s10549-008-9922-7
dc.description.volume113
dc.description.issue2
dc.description.startingpage211
dc.description.endingpage213
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidPentheroudakis, George [0000-0002-6632-2462]
dc.gnosis.orcid0000-0002-2195-9961
dc.gnosis.orcid0000-0002-6632-2462


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