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Transmission of drug-resistant HIV-1 is stabilizing in Europe

dc.contributor.authorVercauteren, J.en
dc.contributor.authorWensing, A. M. J.en
dc.contributor.authorVan De Vijver, D. A. M. C.en
dc.contributor.authorAlbert, Janen
dc.contributor.authorBalotta, Claudiaen
dc.contributor.authorHamouda, O.en
dc.contributor.authorKücherer, C.en
dc.contributor.authorStruck, D.en
dc.contributor.authorSchmit, J. -Cen
dc.contributor.authorÅsjö, Birgittaen
dc.contributor.authorBruckova, M.en
dc.contributor.authorCamacho, Ricardo J.en
dc.contributor.authorClotet, B.en
dc.contributor.authorCoughlan, S.en
dc.contributor.authorGrossman, Z.en
dc.contributor.authorHorban, A.en
dc.contributor.authorKorn, K.en
dc.contributor.authorKostrikis, Leontios G.en
dc.contributor.authorNielsen, C.en
dc.contributor.authorParaskevis, Dimitrios N.en
dc.contributor.authorPoljak, M.en
dc.contributor.authorPuchhammer-Stöckl, E.en
dc.contributor.authorRiva, C.en
dc.contributor.authorRuiz, L.en
dc.contributor.authorSalminen, M.en
dc.contributor.authorSchuurman, R.en
dc.contributor.authorSonnerborg, A.en
dc.contributor.authorStanekova, D.en
dc.contributor.authorStanojevic, M.en
dc.contributor.authorVandamme, A. M.en
dc.contributor.authorBoucher, C. A. B.en
dc.creatorVercauteren, J.en
dc.creatorWensing, A. M. J.en
dc.creatorVan De Vijver, D. A. M. C.en
dc.creatorAlbert, Janen
dc.creatorBalotta, Claudiaen
dc.creatorHamouda, O.en
dc.creatorKücherer, C.en
dc.creatorStruck, D.en
dc.creatorSchmit, J. -Cen
dc.creatorÅsjö, Birgittaen
dc.creatorBruckova, M.en
dc.creatorCamacho, Ricardo J.en
dc.creatorClotet, B.en
dc.creatorCoughlan, S.en
dc.creatorGrossman, Z.en
dc.creatorHorban, A.en
dc.creatorKorn, K.en
dc.creatorKostrikis, Leontios G.en
dc.creatorNielsen, C.en
dc.creatorParaskevis, Dimitrios N.en
dc.creatorPoljak, M.en
dc.creatorPuchhammer-Stöckl, E.en
dc.creatorRiva, C.en
dc.creatorRuiz, L.en
dc.creatorSalminen, M.en
dc.creatorSchuurman, R.en
dc.creatorSonnerborg, A.en
dc.creatorStanekova, D.en
dc.creatorStanojevic, M.en
dc.creatorVandamme, A. M.en
dc.creatorBoucher, C. A. B.en
dc.date.accessioned2019-11-04T12:52:49Z
dc.date.available2019-11-04T12:52:49Z
dc.date.issued2009
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53431
dc.description.abstractThe SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793 patients in 20 European countries and in Israel with newly diagnosed human immunodeficiency virus type 1 (HIV-1) infection. The overall prevalence of TDR was 8.4% (225 of 2687 patientsen
dc.description.abstract95% confidence interval [CI], 7.4%-9.5%), the prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) resistance was 4.7% (125 of 2687 patientsen
dc.description.abstract95% CI, 3.9%-5.5%), the prevalence of nonucleoside reverse-transcriptase inhibitor (NNRTI) resistance was 2.3% (62 of 2687 patientsen
dc.description.abstract95% CI, 1.8%-2.9%), and the prevalence of protease inhibitor (PI) resistance was 2.9% (79 of 2687 patientsen
dc.description.abstract95% CI, 2.4%-3.6%). There was no time trend in the overall TDR or in NRTI resistance, but there was a statistically significant decrease in PI resistance (Pp.04) and in NNRTI resistance after an initial increase (Pp.02). We found that TDR appears to be stabilizing in Europe, consistent with recent reports of decreasing drug resistance and improved viral suppression in patients treated for HIV-1 infection. © 2009 by the Infectious Diseases Society of America. All rights reserved.en
dc.sourceJournal of Infectious Diseasesen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-70449723682&doi=10.1086%2f644505&partnerID=40&md5=0043d40c59e1728ac6600c82c5b88264
dc.subjectEuropeen
dc.subjectarticleen
dc.subjecthumanen
dc.subjectHumansen
dc.subjectadulten
dc.subjectcontrolled studyen
dc.subjectfemaleen
dc.subjectmajor clinical studyen
dc.subjectpriority journalen
dc.subjectdrug effecten
dc.subjectHuman immunodeficiency virus infectionen
dc.subjectmaleen
dc.subjectdisease transmissionen
dc.subjectHIV Infectionsen
dc.subjectvirus transmissionen
dc.subjectprevalenceen
dc.subjectmiddle ageden
dc.subjectgeneticsen
dc.subjectHuman immunodeficiency virus 1en
dc.subjectHIV-1en
dc.subjectnucleotide sequenceen
dc.subjectantiviral resistanceen
dc.subjectHuman immunodeficiency virus 1 infectionen
dc.subjectReverse Transcriptase Inhibitorsen
dc.subjectproteinase inhibitoren
dc.subjecthealth programen
dc.subjectDrug Resistance, Viralen
dc.subjectRNA directed DNA polymerase inhibitoren
dc.subjectunindexed sequenceen
dc.titleTransmission of drug-resistant HIV-1 is stabilizing in Europeen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1086/644505
dc.description.volume200
dc.description.startingpage1503
dc.description.endingpage1508
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :190</p>en
dc.source.abbreviationJ.Infect.Dis.en
dc.contributor.orcidParaskevis, Dimitrios [0000-0001-6167-7152]
dc.gnosis.orcid0000-0001-6167-7152


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