Browsing by Author "Constantinou, Andreas I."
Now showing items 41-60 of 87
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Article
Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells
Nicolaou, Katerina A.; Liapis, Vasilios; Evdokiou, Andreas; Constantinou, Constantina; Magiatis, Prokopios; Skaltsounis, Alexios Leandros; Koumas, Laura; Costeas, Paul A.; Constantinou, Andreas I. (2012)Indirubin derivatives gained interest in recent years for their anticancer and antimetastatic properties. The objective of the present study was to evaluate and compare the anticancer properties of the two novel bromo-substituted ...
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Article
Induction of DNA damage and caspase-independent programmed cell death by vitamin e
Constantinou, Constantina; Neophytou, Christiana M.; Vraka, Panayiota S.; Hyatt, John Anthony; Papas, Konstantinos A.; Constantinou, Andreas I. (2012)Vitamin E comprises 8 functionally unique isoforms and may be a suitable candidate for the adjuvant treatment of prostate cancer. In this study, we examined the ability of 2 vitamin E isoforms [α-tocotrienol (γ-TT) and ...
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Induction of human adenocarcinoma cell differentiation by the phytoestrogen genistein is independent of its antiestrogenic function
Krygier, A. E.; Murley, J. S.; Mehta, R. R.; Constantinou, Andreas I. (1997)The objective of the present study was to determine if genistein can induce human breast adenocarcinoma cell maturation. To gain understanding on its mechanism of action, we used estrogen receptor-positive (ER+) MCF-7, and ...
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Article
Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones
Constantinou, Andreas I.; Mehta, R. G.; Vaughan, A. (1996)Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against breast and prostate cancer. Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against ...
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Article
Inhibition of topoisomerase IIα activity in CHO K1 cells by 2- [(aminopropyl)amino]ethanethiol (WR-1065)
Grdina, D. J.; Constantinou, Andreas I.; Shigematsu, N.; Murley, J. S. (1994)The aminothiol 2-[(aminopropyl)amino]ethanethiol (WR-1065) is the active thiol of the clinically studied radioprotective agent S-2-(3- aminopropylamino)ethylphosphorothioic acid (WR-2721). WR-1065 is an effective radiation ...
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Article
Involvement of host DNA gyrase in growth of bacteriophage T5
Constantinou, Andreas I.; Voelkel-Meiman, K.; Sternglanz, R.; McCorquodale, M. M.; McCorquodale, D. J. (1986)Bacteriophage T5 did not grow at the nonpermissive temperature of 42°C in Escherichia coli carrying a temperature-sensitive mutation in gyrB [gyrB(Ts)], but it did grow in gyrA(Ts) mutants at 42°C. These findings indicate ...
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Article
Isolation of isoflavones from soy-based fermentations of the erythromycin-producing bacterium Saccharopolyspora erythraea
Hessler, P. E.; Larsen, P. E.; Constantinou, Andreas I.; Schram, K. H.; Weber, J. M. (1997)A search for an abundant and economical source of isoflavones, particularly genistein, led to the discovery that the erythromycin-producing organism Saccharopolyspora erythraea also produces this promising new cancer-prevention ...
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Article
LiSIs: An online scientific workflow system for virtual screening
Kannas, Christos C.; Kalvari, Ioanna; Lambrinidis, George; Neophytou, Christiana M.; Savva, Christiana G.; Kirmitzoglou, Ioannis K.; Antoniou, Zinonas C.; Achilleos, Kleo G.; Scherf, D.; Pitta, Chara A.; Nicolaou, Christos A.; Mikros, Emmanuel; Promponas, Vasilis J.; Gerhauser, C.; Mehta, R. G.; Constantinou, Andreas I.; Pattichis, Constantinos S. (2015)Modern methods of drug discovery and development in recent years make a wide use of computational algorithms. These methods utilise Virtual Screening (VS), which is the computational counterpart of experimental screening. ...
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Article
LiSIs: An online scientific workflow system for virtual screeningAAA
Kannas, Christos C.; Kalvari, Ioanna; Lambrinidis, George; Neophytou, Christiana M.; Savva, Christiana G.; Kirmitzoglou, Ioannis K.; Antoniou, Zinonas C.; Achilleos, Kleo G.; Scherf, D.; Pitta, Chara A.; Nicolaou, Christos A.; Mikros, Emmanuel; Promponas, Vasilis J.; Gerhauser, C.; Mehta, R. G.; Constantinou, Andreas I.; Pattichis, Constantinos S. (2015)Modern methods of drug discovery and development in recent years make a wide use of computational algorithms. These methods utilise Virtual Screening (VS), which is the computational counterpart of experimental screening. ...
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Article
A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines
Chen, Y.; Liu, X.; Pisha, E.; Constantinou, Andreas I.; Hua, Y.; Shen, L.; Van Breemen, R. B.; Elguindi, E. C.; Blond, S. Y.; Zhang, Fengwangdong; Bolton, J. L. (2000)Estrogen replacement therapy has been correlated with an increased risk of developing breast or endometrial cancer. 4-Hydroxyequilenin (4-OHEN) is a catechol metabolite of equilenin which is a minor component of the estrogen ...
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Conference Object
Molecular clustering via knowledge mining from biomedical scientific corpora
Hasapis, Panagiotis; Ntalaperas, Dimitrios; Kannas, Christos C.; Aristodimou, Aristos; Alexandrou, Dimitrios Al; Bouras, Thanassis D.; Georgousopoulos, Christos; Antoniades, Athos; Pattichis, Constantinos S.; Constantinou, Andreas I. (2013)In this paper, an architecture is presented that allows the extraction of argumentation clauses that might exist in publications, in order to perform molecular clustering on referenced molecules. Grammar rules are defined ...
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Conference Object
Molecular clustering via knowledge mining from biomedical scientific corporaAAA
Hasapis, Panagiotis; Ntalaperas, Dimitrios; Kannas, Christos C.; Aristodimou, Aristos; Alexandrou, Dimitrios Al; Bouras, Thanassis D.; Georgousopoulos, Christos; Antoniades, Athos; Pattichis, Constantinos S.; Constantinou, Andreas I. (2013)In this paper, an architecture is presented that allows the extraction of argumentation clauses that might exist in publications, in order to perform molecular clustering on referenced molecules. Grammar rules are defined ...
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Article
Monoclonal antibodies to bull sperm surface antigens
Chakraborty, J.; Constantinou, Andreas I.; McCorquodale, M. (1985)Four monoclonal antibodies were generated during the present investigation. Mice were immunized with washed ejaculated bull spermatozoa. Spleen cells from the immunized mice were fused with myeloma cells (SP2/0) and four ...
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Article
Nitrogen mustard up-regulates Bcl-2 and GSH and increases NTP and PCr in HT-29 colon cancer cells
Boddie Jr., A. W.; Constantinou, Andreas I.; Williams, C.; Reed, A. (1998)We hypothesized that unexplained increases in nucleoside triphosphates (NTP) observed by 31P magnetic resonance spectroscopy (MRS) after treatment of tumours by DNA-damaging agents were related to chemotherapy-induced ...
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A novel use for the comet assay: Detection of topoisomerase II inhibitors
Salti, G. I.; Das Gupta, T. K.; Constantinou, Andreas I. (2000)Background: The simple and quick comet assay can quantitatively detect DNA cleavage in cells. This study aimed to determine whether the comet assay could be used to detect topoisomerase (topo) II inhibitors. Materials and ...
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Article
Novobiocin- and Phorbol-12-myristate-13-acetate-induced Differentiation of Human Leukemia Cells Associated with a Reduction in Topoisomerase II Activity
Constantinou, Andreas I.; Henning-Chubb, C.; Huberman, E. (1989)Studies were conducted to determine the possible involvement of DNA topoisomerase II (Topo II) in the induction of differentiation in two human promyelocytic HL-60 leukemia cell variants that are either susceptible or ...
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Article
Pharmaceutical biology: Preface
Constantinou, Andreas I.; Singletary, K. W. (2002)
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Article
Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex
Constantinou, Andreas I.; Husband, A. (2002)Cancer therapeutic drugs that inhibit DNA topoisomerase (topo) II by stabilizing the cleavable complex are collectively known as topo II poisons. Phenoxodiol is a synthetic derivative of the plant isoflavone daidzein and ...
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Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats
Constantinou, Andreas I.; Mehta, R.; Husband, A. (2003)The present study was undertaken to evaluate the potential cancer chemopreventive effects of novel synthetic derivatives of isoflavones. Initially these agents were tested in a mouse mammary organ culture (MMOC) model. ...
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Article
Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo
Georgaki, Sylvianna; Skopeliti, Margarita; Tsiatas, Marinos L.; Nicolaou, Katerina A.; Ioannou, Kyriaki; Husband, A.; Bamias, Aristotelis T.; Dimopoulos, Meletios A.; Constantinou, Andreas I.; Tsitsilonis, Ourania E. (2009)Phenoxodiol (PXD) is a synthetic analogue of the plant isoflavone genistein with improved anticancer efficacy. Various properties and mechanisms of action have been attributed to the drug, the most important being its ...