Browsing by Author "Bagos, Pantelis G."
Now showing items 1-20 of 29
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The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: A mendelian randomization meta-analysis
Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Tsangaris, I.; Tsiara, Chrissa G.; Kopterides, Petros; Vaiopoulos, A.; Kapsimali, Violetta; Bonovas, Stefanos; Tsantes, Argirio E. (2014)Background: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found ...
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Association between the plasminogen activator inhibitor-1 4G/5G gene polymorphism and ischemic stroke; A meta-analysis.
Nikolopoulos, Georgios K.; Tsantes, Argirio E.; Bagos, Pantelis G.; Tsiara, Chrissa G.; Mantzios, Georgios P.; Kapsimali, Violetta; Pappa, Vassiliki; Travlou, Anthi S. (2006)
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Association between the plasminogen activator inhibitor-1 4G/5G polymorphism and venous thrombosis
Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Rapti, E.; Mantzios, Georgios P.; Kapsimali, Violetta; Travlou, Anthi S. (2007)The effect of the 675 insertion/deletion (4G/5G) polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene on the risk of venous thromboembolism (VTE) remains controversial. In this study, we performed a meta-analysis ...
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Bisphosphonate use and risk of colorectal cancer: A systematic review and meta-analysis
Bonovas, Stefanos; Nikolopoulos, Georgios K.; Bagos, Pantelis G. (2013)Aim: A growing body of evidence suggests that bisphosphonates may have chemopreventive potential against colorectal cancer. Our aim was to examine this association through a meta-analysis of observational studies. Methods: ...
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Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials
Bonovas, Stefanos; Nikolopoulos, Georgios K.; Filioussi, K.; Peponi, Evangelia; Bagos, Pantelis G.; Sitaras, N. M. (2010)A growing body of literature suggests that statins may have a chemopreventive potential against melanoma through pleiotropic anti-inflammatory, immunomodulatory, and antiangiogenesis mechanisms. Our aim was to examine this ...
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Chlamydia pneumoniae infection and the risk of multiple sclerosis: A meta-analysis
Bagos, Pantelis G.; Nikolopoulos, Georgios K.; Ioannidis, A. (2006)We conducted a meta-analysis of studies comparing the presence of Chlamydia pneumoniae (Cpn) between multiple sclerosis (MS) patients and other neurological diseases patients or healthy controls. We identified 26 studies ...
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Cytokine gene polymorphisms in multiple sclerosis: A meta-analysis of 45 studies including 7379 cases and 8131 controls
Nikolopoulos, Georgios K.; Masgala, Aikaterini; Tsiara, Chrissa G.; Limitsiou, O. K.; Karnaouri, Anthi C.; Dimou, Niki L.; Bagos, Pantelis G. (2011)Many environmental and genetic factors have been implicated in the development of multiple sclerosis. However, the aetiology has not been clarified yet. Therefore, using a meta-analytic approach, we tried to probe the ...
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Cytokine gene polymorphisms in periodontal disease: A meta-analysis of 53 studies including 4178 cases and 4590 controls
Nikolopoulos, Georgios K.; Dimou, Niki L.; Hamodrakas, Stavros J.; Bagos, Pantelis G. (2008)Aim: We conducted a systematic review and a meta-analysis, in order to investigate the potential association of cytokine gene polymorphisms with either aggressive or chronic periodontal disease. Material and Methods: A ...
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Developing the evidence base for cancer chemoprevention: Use of meta-analysis
Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos (2011)Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an ...
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An ecological study of the determinants of differences in 2009 pandemic influenza mortality rates between countries in Europe
Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Lytras, Theodoros; Bonovas, Stefanos (2011)Background: Pandemic A (H1N1) 2009 mortality rates varied widely from one country to another. Our aim was to identify potential socioeconomic determinants of pandemic mortality and explain between-country variation. ...
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Effect of angiotensin converting enzyme gene I/D polymorphism and its expression on clinical outcome in acute respiratory distress syndrome
Tsantes, Argirio E.; Kopterides, Petros; Bonovas, Stefanos; Bagos, Pantelis G.; Antonakos, Georgios; Nikolopoulos, Georgios K.; Gialeraki, Argiri; Kapsimali, Violetta; Kyriakou, Elias; Kokoris, Styliani; Dima, Kleanthi; Armaganidis, Apostolos; Tsangaris, I. (2013)Background. The role of the D allele of the angiotensin-converting enzyme (ACE) gene I/D polymorphism in the clinical outcomes of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains ...
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Effect of hepatitis C virus on immunological and virological responses in HIV-infected patients initiating highly active antiretroviral therapy: A meta-analysis
Tsiara, Chrissa G.; Nikolopoulos, Georgios K.; Dimou, Niki L.; Bagos, Pantelis G.; Saroglou, G.; Velonakis, E.; Hatzakis, A. (2013)Co-infection of human immunodeficiency virus (HIV) with hepatitis C virus (HCV) is rather common. In the era of highly active antiretroviral therapy (HAART), viral hepatitis could result in adverse outcomes in HIV+ patients. ...
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The effect of homocysteine on the clinical outcomes of ventilated patients with severe sepsis
Tsantes, Argirio E.; Tsangaris, I.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Kopterides, Petros; Antonakos, Georgios; Dimopoulou, Ioanna; Vrioni, G.; Kapsimali, Violetta; Dima, Kleanthi; Armaganidis, Apostolos; Travlou, Anthi S. (2010)Background. There is considerable evidence that elevated plasma homocysteine levels are associated with a prothrombotic milieu, whereas activation of the coagulation cascade is an important component of the pathogenesis ...
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The effect of plasma homocysteine levels on clinical outcomes of patients with acute lung injury/acute respiratory distress syndrome
Tsangaris, I.; Tsantes, Argirio E.; Bagos, Pantelis G.; Nikolopoulos, Georgios K.; Kroupis, C.; Kopterides, Petros; Dimopoulou, Ioanna; Orfanos, S.; Kardoulaki, A.; Chideriotis, S.; Travlou, Anthi S.; Armaganidis, Apostolos (2009)Background: Several reports have shown that homocysteine promotes thrombosis by disturbing the procoagulant-anticoagulant balance, whereas alterations in coagulation and fibrinolysis have been suggested as important ...
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The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk
Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos; Kopterides, Petros; Vaiopoulos, G. (2008)Plasminogen activator inhibitor (PAI-1), is the central component of the fibrinolytic system. A deletion/insertion (4G/5G) polymorphism in the promoter region of the PAI-1 gene has been correlated with levels of plasma ...
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Fc gamma receptor polymorphisms and their association with periodontal disease: a meta-analysis
Dimou, Niki L.; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J.; Bagos, Pantelis G. (2010)Aim: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fc gamma receptor (Fc gamma R) polymorphisms with susceptibility to aggressive and chronic periodontal disease. ...
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Fcγ receptor polymorphisms and their association with periodontal disease: A meta-analysis
Dimou, Niki L.; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J.; Bagos, Pantelis G. (2010)Aim: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fcγ receptor (FcγR) polymorphisms with susceptibility to aggressive and chronic periodontal disease. Materials ...
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Generalized least squares for assessing trends in cumulative meta-analysis with applications in genetic epidemiology
Bagos, Pantelis G.; Nikolopoulos, Georgios K. (2009)Objective: Cumulative meta-analysis allows the evaluation of a study's contribution to the combined effect of the preceding research. It accrues evidence, gradually adding studies one at a time and provides updated estimates ...
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The GNB3 C825T polymorphism and essential hypertension: A meta-analysis of 34 studies including 14 094 cases and 17 760 controls
Bagos, Pantelis G.; Elefsinioti, Antigoni L.; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J. (2007)OBJECTIVES: The C825T single nucleotide polymorphism of the G-protein β3 (GNB3) has been implicated in susceptibility to essential hypertension, through the expression of an alternatively spliced truncated variant. In an ...
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Impact of HIV type 1 DNA levels on spontaneous disease progression: A meta-analysis
Tsiara, Chrissa G.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Goujard, Cecile; Katzenstein, Terese L.; Minga, Albert K.; Rouzioux, C.; Hatzakis, A. (2012)Several studies have reported the prognostic strength of HIV-1 DNA with variable results however. The aims of the current study were to estimate more accurately the ability of HIV-1 DNA to predict progression of HIV-1 ...