Browsing by Author "Bullmore,Edward T."

Now showing items 1-20 of 21

    • Article  

      Atypical neural self-representation in autism 

      Lombardo,Michael V.; Chakrabarti,B.; Bullmore,Edward T.; Sadek,Susan A.; Pasco, Greg; Wheelwright,Sally J.; Suckling,John; Baron-Cohen,Simon (2010)
      The 'self' is a complex multidimensional construct deeply embedded and in many ways defined by our relations with the social world. Individuals with autism are impaired in both self-referential and other-referential social ...
    • Article  

      Biological sex affects the neurobiology of autism 

      Lai,Meng-Chuan; Lombardo,Michael V.; Suckling,John; Ruigrok,Amber N. V.; Chakrabarti,B.; Ecker,C.; Deoni,Sean C. L.; Craig, Michael C.; Murphy,Declan G. M.; Bullmore,Edward T.; Baron-Cohen,Simon (2013)
      In autism, heterogeneity is the rule rather than the exception. One obvious source of heterogeneity is biological sex. Since autism was first recognized, males with autism have disproportionately skewed research. Females ...
    • Article  

      Brain anatomy and its relationship to behavior in adults with autism spectrum disorder: A multicenter magnetic resonance imaging study 

      Ecker,C.; Suckling,John; Deoni,Sean C. L.; Lombardo,Michael V.; Bullmore,Edward T.; Baron-Cohen,Simon; Catani, Marco; Jezzard, Peter; Barnes, Anna; Bailey, Anthony J.; Williams,Steven C. R.; Murphy,Declan G. M. (2012)
      Context: There is consensus that autism spectrum disorder (ASD) is accompanied by differences in neuroanatomy. However, the neural substrates of ASD during adulthood, as well as how these relate to behavioral variation, ...
    • Article  

      Brain surface anatomy in adults with autism: The relationship between surface area, cortical thickness, and autistic symptoms 

      Ecker,C.; Ginestet, Cedric E.; Feng, Yue; Johnston,Patrick; Lombardo,Michael V.; Lai,Meng-Chuan; Suckling,John; Palaniyappan, Lena; Daly,Eileen M.; Murphy,Clodagh M.; Williams,Steven C. R.; Bullmore,Edward T.; Baron-Cohen,Simon; Brammer, Michael; Murphy,Declan G. M. (2013)
      Context: Neuroimaging studies of brain anatomy in autism spectrum disorder (ASD) have mostly been based on measures of cortical volume (CV). However, CV is a product of 2 distinct parameters, cortical thickness (CT) and ...
    • Article  

      Cognition in Males and Females with Autism: Similarities and Differences 

      Lai,Meng-Chuan; Lombardo,Michael V.; Ruigrok,Amber N. V.; Chakrabarti,B.; Wheelwright,Sally J.; Auyeung, Bonnie; Allison, Carrie; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Catani, Marco; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Stewart, R.; Suckling,John; Williams,Steven C. R.; Baron-Cohen,Simon (2012)
      The male bias in autism spectrum conditions (ASC) has led to females with ASC being under-researched. This lack of attention to females could hide variability due to sex that may explain some of the heterogeneity within ...
    • Article  

      Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans 

      Lombardo,Michael V.; Ashwin, Emma; Auyeung, Bonnie; Chakrabarti,B.; Lai,Meng-Chuan; Taylor, Kevin; Hackett, Gerald; Bullmore,Edward T.; Baron-Cohen,Simon (2012)
      Background: Sex differences are present in many neuropsychiatric conditions that affect emotion and approach-avoidance behavior. One potential mechanism underlying such observations is testosterone in early development. ...
    • Article  

      Fetal testosterone influences sexually dimorphic gray matter in the human brain 

      Lombardo,Michael V.; Ashwin, Emma; Auyeung, Bonnie; Chakrabarti,B.; Taylor, Kevin; Hackett, Gerald; Bullmore,Edward T.; Baron-Cohen,Simon (2012)
      In nonhuman species, testosterone is known to have permanent organizing effects early in life that predict later expression of sex differences in brain and behavior. However, in humans, it is still unknown whether such ...
    • Article  

      Frontal networks in adults with autism spectrum disorder 

      Catani, Marco; Dell’Acqua, Flavio; Budisavljevic, Sanja; Howells, Henrietta; Schotten, Thiebaut De; Froudist-Walsh, Sean; D'Anna, Lucio; Thompson, A.; Sandrone, Stefano; Bullmore,Edward T.; Suckling,John; Baron-Cohen,Simon; Lombardo,Michael V.; Wheelwright,Sally J.; Chakrabarti,B.; Lai,Meng-Chuan; Ruigrok,Amber N. V.; Leemans, Alexander; Ecker,C.; Craig, Michael C.; Murphy,Declan G. M.; Bailey, Anthony J.; Bolton, P. F.; Carrington, S.; Daly,Eileen M.; Deoni,Sean C. L.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Spain,D.; Stewart, R.; Williams,Steven C. R. (2016)
      It has been postulated that autism spectrum disorder is underpinned by an 'atypical connectivity' involving higher-order association brain regions. To test this hypothesis in a large cohort of adults with autism spectrum ...
    • Article  

      Improving effect size estimation and statistical power with multi-echo fMRI and its impact on understanding the neural systems supporting mentalizing 

      Lombardo,Michael V.; Auyeung, Bonnie; Holt, R. J.; Waldman, Jack; Ruigrok,Amber N. V.; Mooney, Natasha; Bullmore,Edward T.; Baron-Cohen,Simon; Kundu, Prantik (2016)
      Functional magnetic resonance imaging (fMRI) research is routinely criticized for being statistically underpowered due to characteristically small sample sizes and much larger sample sizes are being increasingly recommended. ...
    • Article  

      Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults 

      Lai,Meng-Chuan; Lombardo,Michael V.; Chakrabarti,B.; Ecker,C.; Sadek,Susan A.; Wheelwright,Sally J.; Murphy,Declan G. M.; Suckling,John; Bullmore,Edward T.; Baron-Cohen,Simon; Bailey, Anthony J.; Bolton, P. F.; Carrington, S.; Daly,Eileen M.; Deoni,Sean C. L.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Pasco, Greg; Ruigrok,Amber N. V.; Spain,D.; Stewart, R.; Williams,Steven C. R. (2012)
      Individual differences in cognitive style can be characterized along two dimensions: 'systemizing' (S, the drive to analyze or build 'rule-based' systems) and 'empathizing' (E, the drive to identify another's mental state ...
    • Article  

      Neuroanatomy of individual differences in language in adult males with autism 

      Lai,Meng-Chuan; Lombardo,Michael V.; Ecker,C.; Chakrabarti,B.; Suckling,John; Bullmore,Edward T.; Happé,Francesca; Murphy,Declan G. M.; Baron-Cohen,Simon (2015)
      One potential source of heterogeneity within autism spectrum conditions (ASC) is language development and ability. In 80 high-functioning male adults with ASC, we tested if variations in developmental and current structural ...
    • Article  

      Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us? 

      Cadman, T.; Spain,D.; Johnston,Patrick; Russell, A.; Mataix-Cols, D.; Craig, Michael C.; Deeley, Q.; Robertson, D. M.; Murphy,Clodagh M.; Gillan, N.; Wilson, C. E.; Mendez, M.; Ecker,C.; Daly,Eileen M.; Findon, J.; Glaser, K.; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Chakrabarti,B.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Lombardo,Michael V.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Steward, R.; Suckling,John; Wheelwright,Sally J.; Williams,Steven C. R.; Happé,Francesca; Murphy,Clodagh M. (2015)
      Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring OCD ...
    • Article  

      On the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis 

      Martinez-Murcia, Francisco; Lai,Meng-Chuan; Górriz, Juan Manuel; Ramirez, Javier; Young, Adam M. H.; Deoni,Sean C. L.; Ecker,C.; Lombardo,Michael V.; MRC AIMS Consortium; Baron-Cohen,Simon; Murphy,Declan G. M.; Bullmore,Edward T.; Suckling,John; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Catani, Marco; Chakrabarti,B.; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Lai,Meng-Chuan; Lombardo,Michael V.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Spain,D.; Stewart, R.; Suckling,John; Wheelwright,Sally J.; Williams,Steven C. R. (2017)
      Neuroimaging studies have reported structural and physiological differences that could help understand the causes and development of Autism Spectrum Disorder (ASD). Many of them rely on multisite designs, with the recruitment ...
    • Article  

      Relationship between cortical gyrification, white matter connectivity, and autism spectrum disorder 

      Ecker,C.; Andrews, Derek Sayre; Dell’Acqua, Flavio; Daly,Eileen M.; Murphy,Clodagh M.; Catani, Marco; Schotten, Thiebaut De; Baron-Cohen,Simon; Lai,Meng-Chuan; Lombardo,Michael V.; Bullmore,Edward T.; Suckling,John; Williams,Steven C. R.; Jones, D. K.; Chiocchetti, A.; Murphy,Declan G. M. (2016)
      Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, which is accompanied by differences in gray matter neuroanatomy and white matter connectivity. However, it is unknown whether these differences are ...
    • Article  

      Relationship between surface-based brain morphometric measures and intelligence in autism spectrum disorders: Influence of history of language delay 

      Balardin, J. B.; Sato, J. R.; Vieira, G.; Feng, Yue; Daly,Eileen M.; Murphy,Clodagh M.; Bailey, Anthony J.; Carrington, S.; Jezzard, Peter; Stewart, R.; Baron-Cohen,Simon; Bullmore,Edward T.; Chakrabarti,B.; Henty, Julian; Lai,Meng-Chuan; Lombardo,Michael V.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Suckling,John; Wheelwright,Sally J.; Bolton, P. F.; Catani, Marco; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Spain,D.; Williams,Steven C. R.; Wilson, C. E.; Murphy,Clodagh M. (2015)
      Autism spectrum disorders (ASD) are a group of conditions that show abnormalities in the neuroanatomy of multiple brain regions. The variability in the development of intelligence and language among individuals on the ...
    • Article  

      A shift to randomness of brain oscillations in people with autism 

      Lai,Meng-Chuan; Lombardo,Michael V.; Chakrabarti,B.; Sadek,Susan A.; Pasco, Greg; Wheelwright,Sally J.; Bullmore,Edward T.; Baron-Cohen,Simon; Suckling,John (2010)
      Background Resting-state functional magnetic resonance imaging (fMRI) enables investigation of the intrinsic functional organization of the brain. Fractal parameters such as the Hurst exponent, H, describe the complexity ...
    • Article  

      Specialization of right temporo-parietal junction for mentalizing and its relation to social impairments in autism 

      Lombardo,Michael V.; Chakrabarti,B.; Bullmore,Edward T.; Baron-Cohen,Simon (2011)
      Over the last 25 years, "mindblindness" (deficits in representing mental states) has been one of the primary explanations behind the hallmark social-communication difficulties in autism spectrum conditions (ASC). However, ...
    • Article  

      A typically rightward cerebral asymmetry in male adults with autism stratifies individuals with and without language delay 

      Floris, Dorothea L.; Lai,Meng-Chuan; Auer, Tibor; Lombardo,Michael V.; Ecker,C.; Chakrabarti,B.; Wheelwright,Sally J.; Bullmore,Edward T.; Murphy,Declan G. M.; Baron-Cohen,Simon; Suckling,John (2016)
      In humans, both language and fine motor skills are associated with left-hemisphere specialization, whereas visuospatial skills are associated with right-hemisphere specialization. Individuals with autism spectrum conditions ...
    • Article  

      Unsupervised data-driven stratification of mentalizing heterogeneity in autism 

      Lombardo,Michael V.; Lai,Meng-Chuan; Auyeung, Bonnie; Holt, R. J.; Allison, Carrie; Smith, P.; Chakrabarti,B.; Ruigrok,Amber N. V.; Suckling,John; Bullmore,Edward T.; Ecker,C.; Craig, Michael C.; Murphy,Declan G. M.; Happé,Francesca; Baron-Cohen,Simon (2016)
      Individuals affected by autism spectrum conditions (ASC) are considerably heterogeneous. Novel approaches are needed to parse this heterogeneity to enhance precision in clinical and translational research. Applying a ...
    • Article  

      White matter microstructural abnormalities in the frontal lobe of adults with antisocial personality disorder 

      Sundram, F.; Deeley, Q.; Sarkar, S.; Daly,Eileen M.; Latham, R.; Craig, Michael C.; Raczek, M.; Fahy, T.; Picchioni, M.; Barker, G. J.; Murphy,Declan G. M.; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Chakrabarti,B.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Lai,Meng-Chuan; Lombardo,Michael V.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Steward, R.; Suckling,John; Wheelwright,Sally J.; Williams,Steven C. R. (2012)
      Antisocial personality disorder (ASPD) and psychopathy involve significant interpersonal and behavioural impairments. However, little is known about their underlying neurobiology and in particular, abnormalities in white ...