Browsing by Author "Felekkis, Kyriacos N."
Now showing items 1-11 of 11
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Article
CNVs-microRNAs interactions demonstrate unique characteristics in the human genome. An interspecies in silico analysis
Dweep, H.; Georgiou, G. D.; Gretz, N.; Constantinou-Deltas, Constantinos D.; Voskarides, Konstantinos; Felekkis, Kyriacos N. (2013)MicroRNAs (miRNAs) and copy number variations (CNVs) represent two classes of newly discovered genomic elements that were shown to contribute to genome plasticity and evolution. Recent studies demonstrated that miRNAs and ...
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Article
Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways
Koupepidou, P.; Felekkis, Kyriacos N.; Kränzlin, B.; Sticht, C.; Gretz, N.; Constantinou-Deltas, Constantinos D. (2010)Background: Polycystic Kidney Disease is characterized by the formation of large fluid-filled cysts that eventually destroy the renal parenchyma leading to end-stage renal failure. Although remarkable progress has been ...
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Article
Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways (BMC Nephrology)
Koupepidou, P.; Felekkis, Kyriacos N.; Kränzlin, B.; Sticht, C.; Gretz, N.; Constantinou-Deltas, Constantinos D. (2011)
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Article
Evidence for activation of the unfolded protein response in collagen iv nephropathies
Pieri, Myrtani; Stefanou, Charalambos; Zaravinos, Apostolos; Erguler, K.; Stylianou, Konstantinos G.; Lapathitis, Georgios; Karaiskos, Christos; Savva, Isavella; Paraskeva, Revekka; Dweep, H.; Sticht, C.; Anastasiadou, Natassa; Zouvani, Ioanna; Goumenos, Dimitrios S.; Felekkis, Kyriacos N.; Saleem, M.; Voskarides, Konstantinos; Gretz, N.; Constantinou-Deltas, Constantinos D. (2014)Thin-basement-membrane nephropathy (TBMN) and Alport syndrome (AS) are progressive collagen IV nephropathies caused by mutations in COL4A3/A4/A5 genes. These nephropathies invariably present with microscopic hematuria and ...
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Article
A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population
Voskarides, Konstantinos; Stefanou, Charalambos; Pieri, Myrtani; Demosthenous, Panayiota; Felekkis, Kyriacos N.; Arsali, Maria; Athanasiou, Yiannis; Xydakis, D.; Stylianou, Konstantinos G.; Daphnis, Eugenios K.; Goulielmos, George N.; Loizou, P.; Savige, J.; Höhne, M.; Völker, L. A.; Benzing, T.; Maxwell, P. H.; Gale, D. P.; Gorski, M.; Böger, C.; Kollerits, B.; Kronenberg, F.; Paulweber, B.; Zavros, Michalis; Pierides, Alkis M.; Constantinou-Deltas, Constantinos D. (2017)Background Recent data emphasize that thin basement membrane nephropathy (TBMN) should not be viewed as a form of benign familial hematuria since chronic renal failure (CRF) and even end-stage renal disease (ESRD), is a ...
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Book
Genomic Elements in Health, Disease and Evolution : Junk DNA
Felekkis, Kyriacos N.; Voskarides, Konstantinos (Springer New York, 2015)
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Article
Increased number of MicroRNA target sites in genes encoded in CNV regions. Evidence for an evolutionary genomic interaction
Felekkis, Kyriacos N.; Voskarides, Konstantinos; Dweep, H.; Sticht, C.; Gretz, N.; Constantinou-Deltas, Constantinos D. (2011)MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome analysis, we demonstrate ...
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Article
MicroRNAs: A newly described class of encoded molecules that play a role in health and disease
Felekkis, Kyriacos N.; Touvana, Evi; Stefanou, Charalambos; Constantinou-Deltas, Constantinos D. (2010)14(4): 236-240.
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Article
A miR-1207-5p binding site polymorphism abolishes regulation of HBEGF and is associated with disease severity in CFHR5 nephropathy
Papagregoriou, Gregory N.; Erguler, K.; Dweep, H.; Voskarides, Konstantinos; Koupepidou, P.; Athanasiou, Yiannis; Pierides, Alkis M.; Gretz, N.; Felekkis, Kyriacos N.; Constantinou-Deltas, Constantinos D. (2012)Heparin binding epidermal growth factor (HBEGF) is expressed in podocytes and was shown to play a role in glomerular physiology. MicroRNA binding sites on the 3′UTR of HBEGF were predicted using miRWalk algorithm and ...
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Article
Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2
Felekkis, Kyriacos N.; Koupepidou, P.; Kastanos, E.; Witzgall, R.; Bai, C. -X; Li, L.; Tsiokas, L.; Gretz, N.; Constantinou-Deltas, Constantinos D. (2008)Background. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in genes ...
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Article
RNA intereference: A powerful laboratory tool and its therapeutic implications
Felekkis, Kyriacos N.; Constantinou-Deltas, Constantinos D. (2006)Ever since RNA intereference (RNAi) was discovered in the early 1990s, a number of scientists from the academic and biotechnology world have continued to view it as the revolutionary discovery of the century. Unequivocally, ...