Browsing by Author "Keravnou, Anna"

Now showing items 1-4 of 4

    • Article  

      Inter-individual methylation variability in differentially methylated regions between maternal whole blood and first trimester CVS 

      Ioannides, Marios; Papageorgiou, Elisavet A.; Keravnou, Anna; Tsaliki, Evdokia; Spyrou, Christiana; Hadjidaniel, Michael D.; Sismani, Carolina; Koumbaris, George L.; Patsalis, Philippos C. (2014)
      Background: DNA methylation is the most studied form of epigenetic regulation, a process by which chromatin composition and transcription factor binding is altered to influence tissue specific gene expression and ...
    • Article  

      MeDIP real-time qPCR of maternal peripheral blood reliably identifies trisomy 21 

      Tsaliki, Evdokia; Papageorgiou, Elisavet A.; Spyrou, Christiana; Koumbaris, George L.; Kypri, Elena; Kyriakou, Skevi; Sotiriou, Chrysovalanto; Touvana, Evi; Keravnou, Anna; Karagrigoriou, Alex; Lamnissou, Klea; Velissariou, Voula; Patsalis, Philippos C. (2012)
      Objective: To reevaluate the efficiency of the 12 differentially methylated regions (DMRs) used in the methylated DNA immunoprecipitation (MeDIP) real-time quantitative polymerase chain reaction (real-time qPCR) based ...
    • Article  

      Targeted capture enrichment assay for non-invasive prenatal testing of large and small size sub-chromosomal deletions and duplications 

      Neofytou, Maria C.; Tsangaras, Kyriakos; Kypri, Elena; Loizides, Charalambos; Ioannides, Marios; Achilleos, Achilleas P.; Mina, Petros; Keravnou, Anna; Sismani, Carolina; Koumbaris, George L.; Patsalis, Philippos C. (2017)
      Noninvasive prenatal testing (NIPT) using whole genome and targeted sequencing has become increasingly accepted for clinical detection of Trisomy 21 and sex chromosome aneuploidies. Few studies have shown that sub-chromosomal ...
    • Article  

      Whole-genome fetal and maternal DNA methylation analysis using MeDIP-NGS for the identification of differentially methylated regions 

      Keravnou, Anna; Ioannides, Marios; Tsangaras, Kyriakos; Loizides, Charalambos; Hadjidaniel, Michael D.; Papageorgiou, Elisavet A.; Kyriakou, Skevi; Antoniou, Pavlos; Mina, Petros; Achilleos, Achilleas P.; Neofytou, Maria C.; Kypri, Elena; Sismani, Carolina; Koumbaris, George L.; Patsalis, Philippos C. (2016)
      DNA methylation is an epigenetic marker that has been shown to vary significantly across different tissues. Taking advantage of the methylation differences between placenta-derived cell-free DNA and maternal blood, several ...