Browsing by Author "Lewis, Nathan E."

Now showing items 1-4 of 4

    • Article  

      The ASD Living Biology: from cell proliferation to clinical phenotype 

      Courchesne, Eric; Pramparo, Tiziano; Gazestani, Vahid H.; Lombardo, Michael V.; Pierce, Karen; Lewis, Nathan E. (2019)
      Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the lay public because of its uncertain origins and striking and unexplained clinical heterogeneity. Here we review genetic, genomic, ...
    • Article  

      Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers 

      Pramparo, Tiziano; Lombardo,Michael V.; Campbell, Kathleen; Barnes, Cynthia Carter; Marinero, S.; Solso, S.; Young, Julia; Mayo, Maisi; Dale, Anders; Ahrens-Barbeau, Clelia; Murray, Sarah S.; Lopez, Linda; Lewis, Nathan E.; Pierce, Karen; Courchesne, Eric (2015)
      Genetic mechanisms underlying abnormal early neural development in toddlers with Autism Spectrum Disorder (ASD) remain uncertain due to the impossibility of direct brain gene expression measurement during critical periods ...
    • Article  

      Hierarchical cortical transcriptome disorganization in autism 

      Lombardo,Michael V.; Courchesne, Eric; Lewis, Nathan E.; Pramparo, Tiziano (2017)
      Background: Autism spectrum disorders (ASD) are etiologically heterogeneous and complex. Functional genomics work has begun to identify a diverse array of dysregulated transcriptomic programs (e.g., synaptic, immune, cell ...
    • Article  

      Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes 

      Lombardo, Michael V.; Pramparo, Tiziano; Gazestani, Vahid; Warrier, Varun; Bethlehem, Richard A. I.; Carter Barnes, Cynthia; Lopez, Linda; Lewis, Nathan E.; Eyler, Lisa; Pierce, Karen; Courchesne, Eric (2018)
      Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes. Here, we identified a large-scale association between multiple ...