Browsing by Author "Neophytou, Christiana M."

Now showing items 1-11 of 11

    • Article  

      Automated scientific assistant for Cancer and Chemoprevention 

      Lazarou, S.; Kakas, Antonis C.; Neophytou, Christiana M.; Constantinou, Andreas I. (2013)
      Logical modeling of cell biological phenomena has the potential to facilitate both the understanding of the mechanisms that underly the phenomena as well as the process of experimentation undertaken by the biologist. ...
    • Doctoral Thesis  Open Access

      Chemotherapeutic mechanism of action of D-Alpha-tocopheryl polyethylene glycol succinate (TPGS) in breast cancer 

      Neophytou, Christiana M. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2014-05)
      Ο καρκίνος του μαστού αποτελεί την πρώτη σε διάγνωση κακοήθεια στις γυναίκες στις Ηνωμένες Πολιτείες και την Ευρώπη. Οι συμβατικές χημειοθεραπευτικές ουσίες συχνά δεν δρουν επιλεκτικά ενάντια στα καρκινικά κύτταρα και ...
    • Article  

      D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells 

      Neophytou, Christiana M.; Constantinou, Constantina; Papageorgis, P.; Constantinou, Andreas I. (2014)
      d-alpha-tocopheryl polyethylene glycol succinate (TPGS) is a vitamin E derivative that has been intensively applied as a vehicle for drug delivery systems to enhance drug solubility and increase the oral bioavailability ...
    • Article  

      Drug delivery innovations for enhancing the anticancer potential of vitamin e isoforms and their derivatives 

      Neophytou, Christiana M.; Constantinou, Andreas I. (2015)
      Vitamin E isoforms have been extensively studied for their anticancer properties. Novel drug delivery systems (DDS) that include liposomes, nanoparticles, and micelles are actively being developed to improve Vitamin E ...
    • Article  

      Induction of caspase-independent programmed cell death by vitamin E natural homologs and synthetic derivatives. 

      Constantinou, Constantina; Hyatt, John Anthony; Vraka, Panayiota S.; Papas, Andreas M.; Papas, Konstantinos A.; Neophytou, Christiana M.; Hadjivassiliou, V.; Constantinou, Andreas I. (2009)
      Current observations in the literature suggest that vitamin E may be a suitable candidate for cancer chemotherapy. To investigate this further, we examined the ability of the vitamin E natural homologs [alpha-, beta-, ...
    • Article  

      Induction of DNA damage and caspase-independent programmed cell death by vitamin e 

      Constantinou, Constantina; Neophytou, Christiana M.; Vraka, Panayiota S.; Hyatt, John Anthony; Papas, Konstantinos A.; Constantinou, Andreas I. (2012)
      Vitamin E comprises 8 functionally unique isoforms and may be a suitable candidate for the adjuvant treatment of prostate cancer. In this study, we examined the ability of 2 vitamin E isoforms [α-tocotrienol (γ-TT) and ...
    • Article  

      LiSIs: An online scientific workflow system for virtual screening 

      Kannas, Christos C.; Kalvari, Ioanna; Lambrinidis, George; Neophytou, Christiana M.; Savva, Christiana G.; Kirmitzoglou, Ioannis K.; Antoniou, Zinonas C.; Achilleos, Kleo G.; Scherf, D.; Pitta, Chara A.; Nicolaou, Christos A.; Mikros, Emmanuel; Promponas, Vasilis J.; Gerhauser, C.; Mehta, R. G.; Constantinou, Andreas I.; Pattichis, Constantinos S. (2015)
      Modern methods of drug discovery and development in recent years make a wide use of computational algorithms. These methods utilise Virtual Screening (VS), which is the computational counterpart of experimental screening. ...
    • Article  

      LiSIs: An online scientific workflow system for virtual screeningAAA 

      Kannas, Christos C.; Kalvari, Ioanna; Lambrinidis, George; Neophytou, Christiana M.; Savva, Christiana G.; Kirmitzoglou, Ioannis K.; Antoniou, Zinonas C.; Achilleos, Kleo G.; Scherf, D.; Pitta, Chara A.; Nicolaou, Christos A.; Mikros, Emmanuel; Promponas, Vasilis J.; Gerhauser, C.; Mehta, R. G.; Constantinou, Andreas I.; Pattichis, Constantinos S. (2015)
      Modern methods of drug discovery and development in recent years make a wide use of computational algorithms. These methods utilise Virtual Screening (VS), which is the computational counterpart of experimental screening. ...
    • Article  

      Selective activation of TNFR1 and NF-ΚB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells 

      Savva, Christiana G.; Totokotsopoulos, S.; Nicolaou, K. C.; Neophytou, Christiana M.; Constantinou, Andreas I. (2016)
      Background: Acquired resistance towards apoptosis is a hallmark of cancer. Elimination of cells bearing activated oncogenes or stimulation of tumor suppressor mediators may provide a selection pressure to overcome resistance. ...
    • Article  

      Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis 

      Papageorgis, P.; Ozturk, S.; Lambert, A. W.; Neophytou, Christiana M.; Tzatsos, Alexandros; Wong, C. K.; Thiagalingam, S.; Constantinou, Andreas I. (2015)
      Introduction: Basal-like breast cancer (BLBC) is an aggressive subtype often characterized by distant metastasis, poor patient prognosis, and limited treatment options. Therefore, the discovery of alternative targets to ...
    • Book Chapter  

      The unknown caspase: The role of caspase-14 in cell death and disease 

      Neophytou, Christiana M.; Theofilou, I.; Constantinou, Andreas I. (Nova Science Publishers, Inc., 2016)
      Caspase-14 is unique among caspase family proteases. It is the shortest member of the caspase family that was first described as a developmentally regulated protease due to its high expression in embryonic tissues. Based ...