Browsing by Author "Voutouri, Chrysovalantis"
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Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness
Voutouri, Chrysovalantis; Stylianopoulos, Triantafyllos (2018)Hyaluronan is abundant in the extracellular matrix of many desmoplastic tumors and determines in large part the tumor biochemical and mechanical microenvironment. Additionally, it has been identified as one of the major ...
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Amphiphilic Polymer Conetworks Based on End-Linked "core-First" Star Block Copolymers: Structure Formation with Long-Range Order
Kepola, Eleni J.; Loizou, Elena; Patrickios, Costas S.; Leontidis, Epameinondas; Voutouri, Chrysovalantis; Stylianopoulos, Triantafyllos; Schweins, R.; Gradzielski, M.; Krumm, C.; Tiller, J. C.; Kushnir, M.; Wesdemiotis, Chrystostomos (2015)Amphiphilic polymer conetworks are cross-linked polymers that swell both in water and in organic solvents and can phase separate on the nanoscale in the bulk or in selective solvents. To date, however, this phase separation ...
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Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment
Martin, John D.; Panagi, Myrofora; Wang, Chenyu; Khan, Thahomina T.; Martin, Margaret R.; Voutouri, Chrysovalantis; Toh, Kazuko; Papageorgis, Panagiotis; Mpekris, Fotios; Polydorou, Christiana; Ishii, Genichiro; Takahashi, Shinichiro; Gotohda, Naoto; Suzuki, Toshiyuki; Wilhelm, Matthew E.; Melo, Vinicio Alejandro; Quader, Sabina; Norimatsu, Jumpei; Lanning, Ryan M.; Kojima, Motohiro; Stuber, Matthew David; Stylianopoulos, Triantafyllos; Kataoka, Kazunori; Cabral, Horacio (2019)Dexamethasone is a glucocorticoid steroid with anti-inflammatory properties used to treat many diseases, including cancer, in which it helps manage various side effects of chemo-, radio-, and immunotherapies. Here, we ...
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Double-networks based on interconnected amphiphilic “in–out” star first polymer conetworks prepared by RAFT polymerization
Kitiri, Elina N.; Varnava, Constantina K.; Patrickios, Costas S.; Voutouri, Chrysovalantis; Stylianopoulos, Triantafyllos; Gradzielski, Michael; Hoffmann, Ingo (2018)Double-network hydrogels were prepared using well-defined first networks comprising interconnected amphiphilic “in-out” star copolymers synthesized via sequential reversible addition-fragmentation chain transfer (RAFT) ...
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Double-networks based on pH-responsive, amphiphilic "core-first" star first polymer conetworks prepared by sequential RAFT polymerization
Kitiri, E. N.; Patrickios, Costas S.; Voutouri, Chrysovalantis; Stylianopoulos, Triantafyllos; Hoffmann, I.; Schweins, R.; Gradzielski, M. (2017)This manuscript presents the preparation and study of a new double-network hydrogel system, comprising an amphiphilic, pH-responsive first polymer conetwork synthesized via reversible addition-fragmentation chain transfer ...
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Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies
Voutouri, Chrysovalantis; Kirkpatrick, Nathaniel D.; Chung, Euiheon; Mpekris, Fotios; Baish, James W.; Munn, Lance L.; Fukumura, Dai; Stylianopoulos, Triantafyllos; Jain, Rakesh K. (2019)Cooption of the host vasculature is a strategy that some cancers use to sustain tumor progression without—or before—angiogenesis or in response to antiangiogenic therapy. Facilitated by certain growth factors, cooption can ...
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Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression
Kalli, Maria; Voutouri, Chrysovalantis; Minia, Angeliki; Pliaka, Vaia; Fotis, Christos; Alexopoulos, Leonidas G.; Stylianopoulos, Triantafyllos (2019)Mechanical compression is a common abnormality of brain tumors that has been shown to be responsible for the severe neurological defects of brain cancer patients representing a negative prognostic factor. Indeed, it is of ...
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Stress alleviation strategy in cancer treatment: Insights from a mathematical model
Mpekris, Fotios; Voutouri, Chrysovalantis; Papageorgis, Panagiotis; Stylianopoulos, Triantafyllos (2018)Tumors generate mechanical forces during growth and progression, which are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. Tumor vessels—while nourishing the tumor—are usually ...
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Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner
Papageorgis, P.; Polydorou, Christiana; Mpekris, Fotios; Voutouri, Chrysovalantis; Agathokleous, Eliana A.; Kapnissi‐Christodoulou, Constantina P.; Stylianopoulos, Triantafyllos (2017)Accumulation of mechanical stresses during cancer progression can induce blood and lymphatic vessel compression, creating hypo-perfusion, hypoxia and interstitial hypertension which decrease the efficacy of chemo- and ...
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Tuning the Mechanical Properties of BIEE-Crosslinked Semi-Interpenetrating, Double-Hydrophilic Hydrogels
Papaparaskeva, Georgia; Voutouri, Chrysovalantis; Gkretsi, Vasiliki; Achilleos, Mariliz; Safarik, Ivo; Pospiskova, Kristyna; Stylianopoulos, Triantafyllos; Krasia‐Christoforou, Theodora (2018)Double-hydrophilic, semi-interpenetrating (semi-IPN) hydrogels are synthesized by encapsulating hydrophilic polyvinylpyrrolidone (PVP) linear chains in structure-defined 1,2-bis-(2-iodoethoxy)ethane (BIEE)-crosslinked ...