Browsing by Subject "Mice, Inbred C57BL"
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Article
FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases
(2009)Aging is a risk factor for the development of adult-onset neurodegenerative diseases. Although some of the molecular pathways regulating longevity and stress resistance in lower organisms are defined (i.e., those activating ...
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Article
The Ink4/Arf locus is a barrier for iPS cell reprogramming
(2009)The mechanisms involved in the reprogramming of differentiated cells into induced pluripotent stem (iPS) cells by the three transcription factors Oct4 (also known as Pou5f1), Klf4 and Sox2 remain poorly understood. The ...
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Article
Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells
(2009)Telomere shortening is associated with organismal aging. iPS cells have been recently derived from old patients