Browsing by Subject "Pluripotent Stem Cells"

Now showing items 1-4 of 4

    • Article  

      The Ink4/Arf locus is a barrier for iPS cell reprogramming 

      Li, H.; Collado, M.; Villasante, A.; Strati, Katerina; Ortega, S.; Cãamero, M.; Blasco, M. A.; Serrano, M. (2009)
      The mechanisms involved in the reprogramming of differentiated cells into induced pluripotent stem (iPS) cells by the three transcription factors Oct4 (also known as Pou5f1), Klf4 and Sox2 remain poorly understood. The ...
    • Article  

      A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity 

      Marión, R. M.; Strati, Katerina; Li, H.; Murga, M.; Blanco, R.; Ortega, S.; Fernandez-Capetillo, O.; Serrano, M.; Blasco, M. A. (2009)
      The reprogramming of differentiated cells to pluripotent cells (induced pluripotent stem (iPS) cells) is known to be an inefficient process. We recently reported that cells with short telomeres cannot be reprogrammed to ...
    • Article  

      Shared mechanisms in stemness and carcinogenesis: Lessons from oncogenic viruses 

      Iacovides, D.; Michael, S.; Achilleos, Charis; Strati, Katerina (2013)
      A rise in technologies for epigenetic reprogramming of cells to pluripotency, highlights the potential of understanding and manipulating cellular plasticity in unprecedented ways. Increasing evidence points to shared ...
    • Article  

      Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells 

      Marion, R. M.; Strati, Katerina; Li, H.; Tejera, A.; Schoeftner, S.; Ortega, S.; Serrano, M.; Blasco, M. A. (2009)
      Telomere shortening is associated with organismal aging. iPS cells have been recently derived from old patients