Browsing by Subject "cre recombinase"

Now showing items 1-2 of 2

    • Article  

      Trophoblast-specific gene manipulation using lentivirus-based vectors 

      Georgiades, Pantelis; Cox, B.; Gertsenstein, M.; Chawengsaksophak, K.; Rossant, J. (2007)
      The trophoblast layers of the mammalian placenta carry out many complex functions required to pattern the developing embryo and maintain its growth and survival in the uterine environment. Genetic disruption of many gene ...
    • Article  

      vavCre transgenic mice: A tool for mutagenesis in hematopoietic and endothelial lineages 

      Georgiades, Pantelis; Ogilvy, S.; Duval, H.; Licence, D. R.; Charnock-Jones, D. S.; Smith, S. K.; Print, C. G. (2002)
      Cre transgenic mice can be used to delete gene sequences flanked by loxP sites in specific somatic tissues. We have generated vavCre transgenic mice, which can be used to inactivate genes specifically in adult hematopoietic ...