Browsing by Subject "endocytosis"

Now showing items 1-4 of 4

    • Article  

      Delivering nanomedicine to solid tumors 

      Jain, R. K.; Stylianopoulos, T. (2010)
      Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using nanoparticles to treat ...
    • Article  

      The interplay between DSL proteins and ubiquitin ligases in Notch signaling 

      Pitsouli, Chrysoula; Delidakis, Christos (2005)
      Lateral inhibition is a pattern refining process that generates single neural precursors from a field of equipotent cells and is mediated via Notch signaling. Of the two Notch ligands Delta and Serrate, only the former was ...
    • Article  

      Neuralized Encodes a Peripheral Membrane Protein Involved in Delta Signaling and Endocytosis 

      Pavlopoulos, Elias; Pitsouli, Chrysoula; Klueg, K. M.; Muskavitch, M. A. T.; Moschonas, Nicholas K.; Delidakis, Christos (2001)
      Activation of the Notch (N) receptor involves an intracellular proteolytic step triggered by shedding of the extracellular N domain (N-EC) upon ligand interaction. The ligand Dl has been proposed to effect this N-EC shedding ...
    • Article  

      A small molecule mimicking a phosphatidylinositol (4,5)-bisphosphate binding pleckstrin homology domain 

      Mak, L. H.; Georgiades, Savvas N.; Rosivatz, E.; Whyte, G. F.; Mirabelli, M.; Vilar, R.; Woscholski, R. (2011)
      Inositol phospholipids have emerged as important key players in a wide variety of cellular functions. Among the seven existing inositol phospholipids, phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) has attracted much ...