Browsing by Subject "pluripotent stem cell"
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Article
The Ink4/Arf locus is a barrier for iPS cell reprogramming
(2009)The mechanisms involved in the reprogramming of differentiated cells into induced pluripotent stem (iPS) cells by the three transcription factors Oct4 (also known as Pou5f1), Klf4 and Sox2 remain poorly understood. The ...
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A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
(2009)The reprogramming of differentiated cells to pluripotent cells (induced pluripotent stem (iPS) cells) is known to be an inefficient process. We recently reported that cells with short telomeres cannot be reprogrammed to ...
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Article
Shared mechanisms in stemness and carcinogenesis: Lessons from oncogenic viruses
(2013)A rise in technologies for epigenetic reprogramming of cells to pluripotency, highlights the potential of understanding and manipulating cellular plasticity in unprecedented ways. Increasing evidence points to shared ...
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Article
Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells
(2009)Telomere shortening is associated with organismal aging. iPS cells have been recently derived from old patients