Browsing by Subject "tumor vascularization"

Now showing items 1-10 of 10

    • Article  

      Delivering nanomedicine to solid tumors 

      Jain, R. K.; Stylianopoulos, T. (2010)
      Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using nanoparticles to treat ...
    • Article  

      Multistage nanoparticle delivery system for deep penetration into tumor tissue 

      Wong, C.; Stylianopoulos, T.; Cui, J.; Martin, J.; Chauhan, V. P.; Jiang, W.; Popovic, Z.; Jain, R. K.; Bawendi, M. G.; Fukumura, D. (2011)
      Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...
    • Article  

      Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner 

      Chauhan, V. P.; Stylianopoulos, T.; Martin, J. D.; PopoviÄ, Z.; Chen, O.; Kamoun, W. S.; Bawendi, M. G.; Fukumura, D.; Jain, R. K. (2012)
      The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic ...
    • Article  

      Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy 

      Stylianopoulos, T.; Munn, L. L.; Jain, R. K. (2018)
      [Figure presented] A solid tumor is like an aberrant organ – comprised of cancer cells and a variety of host cells embedded in an extracellular matrix – nourished by blood vessels and drained by lymphatic vessels. In its ...
    • Article  

      Remodeling components of the tumor microenvironment to enhance cancer therapy 

      Gkretsi, V.; Stylianou, A.; Papageorgis, P.; Polydorou, C.; Stylianopoulos, T. (2015)
      Solid tumor pathophysiology is characterized by an abnormal microenvironment that guides tumor progression and poses barriers to the efficacy of cancer therapies. Most common among tumor types are abnormalities in the ...
    • Article  

      The role of mechanical forces in tumor growth and therapy 

      Jain, R. K.; Martin, J. D.; Stylianopoulos, T. (2014)
      Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...
    • Article  

      Role of vascular normalization in benefit from metronomic chemotherapy 

      Mpekris, F.; Baish, J. W.; Stylianopoulos, T.; Jain, R. K. (2017)
      Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in ...
    • Article  

      Targeting Inflammation to Improve Tumor Drug Delivery 

      Gkretsi, V.; Zacharia, L. C.; Stylianopoulos, T. (2017)
      Inefficient delivery of drugs is a main cause of chemotherapy failure in hypoperfused tumors. To enhance perfusion and drug delivery in these tumors, two strategies have been developed: vascular normalization, aiming at ...
    • Article  

      Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging 

      Vakoc, B. J.; Lanning, R. M.; Tyrrell, J. A.; Padera, T. P.; Bartlett, L. A.; Stylianopoulos, T.; Munn, L. L.; Tearney, G. J.; Fukumura, D.; Jain, R. K.; Bouma, Brett E. (2009)
      Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous ...
    • Article  

      A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth 

      Vavourakis, V.; Wijeratne, P. A.; Shipley, R.; Loizidou, M.; Stylianopoulos, T.; Hawkes, D. J. (2017)
      Vascularisation is a key feature of cancer growth, invasion and metastasis. To better understand the governing biophysical processes and their relative importance, it is instructive to develop physiologically representative ...