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dc.contributor.authorCharman, T.en
dc.contributor.authorLoth, Evaen
dc.contributor.authorTillmann, Julianen
dc.contributor.authorCrawley, Daisyen
dc.contributor.authorWooldridge, C.en
dc.contributor.authorGoyard, Daviden
dc.contributor.authorAhmad, Jumanaen
dc.contributor.authorAuyeung, Bonnieen
dc.contributor.authorAmbrosino, Saraen
dc.contributor.authorBanaschewski, Tobiasen
dc.contributor.authorBaron-Cohen,Simonen
dc.contributor.authorBaumeister, Sarahen
dc.contributor.authorBeckmann, Christianen
dc.contributor.authorBölte, Svenen
dc.contributor.authorBourgeron, Thomasen
dc.contributor.authorBours, Carstenen
dc.contributor.authorBrammer, Michaelen
dc.contributor.authorBrandeis, Danielen
dc.contributor.authorBrogna, Claudiaen
dc.contributor.authorDe Bruijn, Y.en
dc.contributor.authorChakrabarti,B.en
dc.contributor.authorCornelissen, Inekeen
dc.contributor.authorAcqua, Flavio Dellen
dc.contributor.authorDumas, G.en
dc.contributor.authorDurston, Sarahen
dc.contributor.authorEcker,C.en
dc.contributor.authorFaulkner, J.en
dc.contributor.authorFrouin, Vincenten
dc.contributor.authorGarces, Pilaren
dc.contributor.authorHam, Lindsay M.en
dc.contributor.authorHayward, Hannahen
dc.contributor.authorHipp, Joergen
dc.contributor.authorHolt, R. J.en
dc.contributor.authorIsaksson, Johanen
dc.contributor.authorJohnson, Mark H.en
dc.contributor.authorJones, Emily J. H.en
dc.contributor.authorKundu, Prantiken
dc.contributor.authorLai,Meng-Chuanen
dc.contributor.authorD'Ardhuy, X. L.en
dc.contributor.authorLombardo,Michael V.en
dc.contributor.authorLythgoe, David J.en
dc.contributor.authorMandl, Reneen
dc.contributor.authorMason, Lukeen
dc.contributor.authorMeyer-Lindenberg, Andreasen
dc.contributor.authorMoessnang, Carolinen
dc.contributor.authorMueller, Nicoen
dc.contributor.authorO'Dwyer, Laurenceen
dc.contributor.authorOldehinkel, Marianneen
dc.contributor.authorOranje, Boben
dc.contributor.authorPandina, Gahan J.en
dc.contributor.authorPersico, Antonio M.en
dc.contributor.authorRuggeri, B.en
dc.contributor.authorRuigrok,Amber N. V.en
dc.contributor.authorSabet, Jessicaen
dc.contributor.authorSacco, Robertoen
dc.contributor.authorCaceres, Antonia San Joseen
dc.contributor.authorSimonoff, Emilyen
dc.contributor.authorToro, Robertoen
dc.contributor.authorTost, Heikeen
dc.contributor.authorWaldman, Jacken
dc.contributor.authorWilliams,Steven C. R.en
dc.contributor.authorZwiers, Marcel P.en
dc.contributor.authorSpooren, Willen
dc.contributor.authorMurphy,Declan G. M.en
dc.contributor.authorBuitelaar, Jan K.en
dc.creatorCharman, T.en
dc.creatorLoth, Evaen
dc.creatorTillmann, Julianen
dc.creatorCrawley, Daisyen
dc.creatorWooldridge, C.en
dc.creatorGoyard, Daviden
dc.creatorAhmad, Jumanaen
dc.creatorAuyeung, Bonnieen
dc.creatorAmbrosino, Saraen
dc.creatorBanaschewski, Tobiasen
dc.creatorBaron-Cohen,Simonen
dc.creatorBaumeister, Sarahen
dc.creatorBeckmann, Christianen
dc.creatorBölte, Svenen
dc.creatorBourgeron, Thomasen
dc.creatorBours, Carstenen
dc.creatorBrammer, Michaelen
dc.creatorBrandeis, Danielen
dc.creatorBrogna, Claudiaen
dc.creatorDe Bruijn, Y.en
dc.creatorChakrabarti,B.en
dc.creatorCornelissen, Inekeen
dc.creatorAcqua, Flavio Dellen
dc.creatorDumas, G.en
dc.creatorDurston, Sarahen
dc.creatorEcker,C.en
dc.creatorFaulkner, J.en
dc.creatorFrouin, Vincenten
dc.creatorGarces, Pilaren
dc.creatorHam, Lindsay M.en
dc.creatorHayward, Hannahen
dc.creatorHipp, Joergen
dc.creatorHolt, R. J.en
dc.creatorIsaksson, Johanen
dc.creatorJohnson, Mark H.en
dc.creatorJones, Emily J. H.en
dc.creatorKundu, Prantiken
dc.creatorLai,Meng-Chuanen
dc.creatorD'Ardhuy, X. L.en
dc.creatorLombardo, Michael V.en
dc.creatorLythgoe, David J.en
dc.creatorMandl, Reneen
dc.creatorMason, Lukeen
dc.creatorMeyer-Lindenberg, Andreasen
dc.creatorMoessnang, Carolinen
dc.creatorMueller, Nicoen
dc.creatorO'Dwyer, Laurenceen
dc.creatorOldehinkel, Marianneen
dc.creatorOranje, Boben
dc.creatorPandina, Gahan J.en
dc.creatorPersico, Antonio M.en
dc.creatorRuggeri, B.en
dc.creatorRuigrok,Amber N. V.en
dc.creatorSabet, Jessicaen
dc.creatorSacco, Robertoen
dc.creatorCaceres, Antonia San Joseen
dc.creatorSimonoff, Emilyen
dc.creatorToro, Robertoen
dc.creatorTost, Heikeen
dc.creatorWaldman, Jacken
dc.creatorWilliams,Steven C. R.en
dc.creatorZwiers, Marcel P.en
dc.creatorSpooren, Willen
dc.creatorMurphy,Declan G. M.en
dc.creatorBuitelaar, Jan K.en
dc.date.accessioned2017-07-27T10:21:29Z
dc.date.available2017-07-27T10:21:29Z
dc.date.issued2017
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/37133
dc.description.abstractBackground: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers. Methods: From six research centres in four European countries, we recruited 437 children and adults with ASD and 300 controls between the ages of 6 and 30 years with IQs varying between 50 and 148. We conducted in-depth clinical characterisation including a wide range of observational, interview and questionnaire measures of the ASD phenotype, as well as co-occurring psychiatric symptoms. Results: The cohort showed heterogeneity in ASD symptom presentation, with only minimal to moderate site differences on core clinical and cognitive measures. On both parent-report interview and questionnaire measures, ASD symptom severity was lower in adults compared to children and adolescents. The precise pattern of differences varied across measures, but there was some evidence of both lower social symptoms and lower repetitive behaviour severity in adults. Males had higher ASD symptom scores than females on clinician-rated and parent interview diagnostic measures but not on parent-reported dimensional measures of ASD symptoms. In contrast, self-reported ASD symptom severity was higher in adults compared to adolescents, and in adult females compared to males. Higher scores on ASD symptom measures were moderately associated with lower IQ. Both inattentive and hyperactive/impulsive ADHD symptoms were lower in adults than in children and adolescents, and males with ASD had higher levels of inattentive and hyperactive/impulsive ADHD symptoms than females. Conclusions: The established phenotypic heterogeneity in ASD is well captured in the LEAP cohort. Variation both in core ASD symptom severity and in commonly co-occurring psychiatric symptoms were systematically associated with sex, age and IQ. The pattern of ASD symptom differences with age and sex also varied by whether these were clinician ratings or parent- or self-reported which has important implications for establishing stratification biomarkers and for their potential use as outcome measures in clinical trials. © 2017 The Author(s).en
dc.sourceMolecular Autismen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85021142828&doi=10.1186%2fs13229-017-0145-9&partnerID=40&md5=c3c8b9567a5cb8bfdcf125d0eeb27876
dc.subjectAgeen
dc.subjectAutismen
dc.subjectAutism spectrum disorderen
dc.subjectBehavioursen
dc.subjectHeterogeneityen
dc.subjectIqen
dc.subjectPhenotypeen
dc.subjectSexen
dc.titleThe EU-AIMS Longitudinal European Autism Project (LEAP): Clinical characterisationen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1186/s13229-017-0145-9
dc.description.volume8
dc.description.issue1
dc.author.facultyΣχολή Κοινωνικών Επιστημών και Επιστημών Αγωγής / Faculty of Social Sciences and Education
dc.author.departmentΤμήμα Ψυχολογίας / Department of Psychology
dc.type.uhtypeArticleen
dc.description.notesExport Date: 17 July 2017en
dc.contributor.orcidLombardo, Michael V. [0000-0001-6780-8619]
dc.gnosis.orcid0000-0001-6780-8619


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