Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Title

Now showing items 276-295 of 677

    • Article  

      Habitat diversity, ecological requirements of species and the Small Island Effect 

      Sfenthourakis, Spyros; Triantis, Kostas A. (2009)
      Aim: To explore the causal factors leading to a significant Small Island Effect (SIE), that is, the absence of the commonly found species-area relationships below an island size, on the terrestrial isopod communities from ...
    • Article  

      Haploinsufficiency of the miR-873/miR-876 microRNA cluster is associated with craniofacial abnormalities 

      Koufaris, Costas; Papagregoriou, Gregory N.; Kousoulidou, Ludmila; Moutafi, Maria; Tauber, Maïthé Thérèse; Jouret, Béatrice; Kieffer, Isabelle; Constantinou-Deltas, Constantinos D.; Tanteles, George A.; Anastasiadou, Violetta C.; Patsalis, Philippos C.; Sismani, Carolina (2015)
      MicroRNA haploinsufficiency has been associated with developmental defects in only a limited number of cases. Here we report a de novo genomic microdeletion that includes the LINGO2 gene as well as two microRNA genes, ...
    • Article  

      hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies 

      Drakou, Christina E.; Malekkou, A.; Hayes, Joseph M.; Lederer, C. W.; Leonidas, Demetres D.; Oikonomakos, Nikos G.; Lamond, A. I.; Santama, Niovi; Zographos, Spyros E. (2012)
    • Article  

      HCV Phylogeography of the General Population and High-Risk Groups in Cyprus Identifies the Island as a Global Sink for and Source of Infection 

      Paraskevis, Dimitrios; Stylianou, Dora C.; Hezka, Johana; Stern, Zachariah; Oikonomopoulou, Martha; Mamais, Ioannis; Kostrikis, Leondios G. (2019)
      Hepatitis C virus (HCV) genotype and subtype distribution differs according to geographic origin and transmission risk category. Previous molecular epidemiology studies suggest the presence of multiple subtypes among Cypriot ...
    • Article  

      Hedgehog restricts its expression domain in the Drosophila wing 

      Bejarano, F.; Pérez, L.; Apidianakis, Yiorgos; Delidakis, Christos; Milán, M. (2007)
      The stable subdivision of Drosophila limbs into anterior and posterior compartments is a consequence of asymmetrical signalling by Hedgehog (Hh), from the posterior to anterior cells. The activity of the homeodomain protein ...
    • Article  

      Hepatitis C infection among intravenous drug users attending therapy programs in Cyprus 

      Demetriou, Victoria L.; Van De Vijver, D. A. M. C.; Hezka, Johana; Kostrikis, Leontios G.; Savvopoulou, Natasa; Georgiades, Neoklis; Charilaou, Charis C.; Argyriou, Argyris; Pavlou, Tina; Platritis, Kyriakos; Veresies, Kyriakos L. (2010)
      The most high-risk population for HCV transmission worldwide today are intravenous drug users. HCV genotypes in the general population in Cyprus demonstrate a polyphyletic infection and include subtypes associated with ...
    • Article  

      Hepatitis C infection among intravenous drug users attending therapy programs in Cyprus (Journal of Medical Virology (2010) 82, (263-270)) 

      Demetriou, Victoria L.; Van De Vijver, D. A. M. C.; Hezka, Johana; Kostrikis, Leontios G. (2010)
    • Article  

      Hepatitis C virus infection epidemiology among people who inject drugs in europe: A systematic review of data for scaling up treatment and prevention 

      Wiessing, L.; Ferri, M.; Grady, B.; Kantzanou, M.; Sperle, I.; Cullen, K. J.; Hatzakis, Angelos E.; Prins, M.; Vickerman, P.; Lazarus, J. V.; Hope, V. D.; Matheï, C.; Busch, M.; Bollaerts, K.; Bogdanova, V.; Nesheva, E.; Fotsiou, N.; Kostrikis, Leontios G.; Mravčík, V.; Řehák, V.; Částková, J.; Hobstová, J.; Nechanská, B.; Fouchard, J.; Abel-Ollo, K.; Tefanova, V.; Tallo, T.; Brummer-Korvenkontio, H.; Brisacier, A. -C; Michot, I.; Jauffret-Roustide, M.; Zimmermann, R.; Fotiou, A.; Gazdag, G.; Tarján, A.; Galvin, B.; Thornton, L.; Cruciani, M.; Basso, M.; Karnite, A.; Caplinskiene, I.; Lopes, S.; Origer, A.; Melillo, J.; Camilleri, M.; Demanuele, C. O.; Croes, E.; Op De Coul, E.; Rosińska, M.; Struzik, M.; Martins, M.; Duran, D.; Vilar, G.; Resende, M. E.; Martins, H. C.; Abagiu, A. O.; Ruta, S.; Arama, V.; Kopilovic, B.; Kustec, T.; Klavs, I.; Aleixandre, N. L.; Folch, C.; Bravo, M. J.; Gómez, R. S.; Berglund, T.; Strandberg, J.; Hotho, D.; Van Houdt, S.; Low, A.; Mcdonald, B.; Platt, L.; Kalamara, E.; Giraudon, I.; Groshkova, T.; Palladino, C.; Hutchinson, S.; Ncube, F.; Eramova, I.; Goldberg, D.; Vicente, J.; Griffiths, P. (2014)
      Background: People who inject drugs (PWID) are a key population affected by hepatitis C virus (HCV). Treatment options are improving and may enhance prevention
    • Article  

      High-resolution whole-mount in situ hybridization using quantum dot nanocrystals 

      Ioannou, Androulla; Eleftheriou, Iro; Lubatti, Andrea; Charalambous, Anna; Skourides, Paris A. (2012)
      The photostability and narrow emission spectra of nanometer-scale semiconductor crystallites (QDs) make them desirable candidates for whole-mount fluorescent in situ hybridization to detect mRNA transcripts in morphologically ...
    • Article  

      Histone H3 tail clipping regulates gene expression 

      Santos-Rosa, H.; Kirmizis, Antonis; Nelson, C.; Bartke, T.; Saksouk, N.; Cote, J.; Kouzarides, T. (2009)
      Induction of gene expression in yeast and human cells involves changes in the histone modifications associated with promoters. Here we identify a histone H3 endopeptidase activity in Saccharomyces cerevisiae that may ...
    • Article  

      Histone Modifications as an Intersection Between Diet and Longevity 

      Molina-Serrano, Diego; Kyriakou, Dimitris; Kirmizis, Antonis (2019)
      Histone modifications are key epigenetic regulators that control chromatin structure and gene transcription, thereby impacting on various important cellular phenotypes. Over the past decade, a growing number of studies ...
    • Article  

      HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier: A Densely Sampled Transmission Dynamics Analysis from 1986 to 2012 

      Pineda-Peña, Andrea-Clemencia; Theys, Kristof; Stylianou, Dora C.; Demetriades, Ioannis; Abecasis, Ana B.; Kostrikis, Leondios G. (2018)
      Since HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically ...
    • Article  

      HIV-1 integrase: From biology to chemotherapeutics 

      Zeinalipour-Loizidou, E.; Nicolaou, Charalambos P.; Nicolaïdes, Andrew N.; Kostrikis, Leontios G. (2007)
      AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of ...
    • Article  

      HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics 

      Abecasis, A. B.; Wensing, A. M. J.; Paraskevis, Dimitrios N.; Vercauteren, J.; Theys, K.; Van de Vijver, D. A. M. C.; Albert, Jan; Åsjö, Birgitta; Balotta, Claudia; Beshkov, Danail; Camacho, Ricardo J.; Clotet, B.; De Gascun, C.; Griskevicius, A.; Grossman, Z.; Hamouda, O.; Horban, A.; Kolupajeva, T.; Korn, K.; Kostrikis, Leontios G.; Kücherer, C.; Liitsola, K.; Linka, M.; Nielsen, C.; Otelea, D.; Paredes, R.; Poljak, M.; Puchhammer-Stöckl, E.; Schmit, J. -C; Sönnerborg, A.; Stanekova, D.; Stanojevic, M.; Struck, D.; Boucher, C. A. B.; Vandamme, A. -M (2013)
      Background: Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, ...
    • Article  

      HIV-1 transmission networks across Cyprus (2010-2012) 

      Kostrikis, Leondios G.; Hezka, Johana; Stylianou, Dora C.; Kostaki, Evangelia; Andreou, Maria; Kousiappa, Ioanna; Paraskevis, Dimitrios; Demetriades, Ioannis (2018)
      A molecular epidemiology study of HIV-1 infection was conducted in one hundred diagnosed and untreated HIV-1-infected patients in Cyprus between 2010 and 2012, representing 65.4% of all the reported HIV-1 infections in ...
    • Article  

      HIV-1 vaccine strategies utilizing viral vectors including antigen-displayed inoviral vectors 

      Hassapis, K. A.; Kostrikis, Leontios G. (2013)
      Antigen-presenting viral vectors have been extensively used as vehicles for the presentation of antigens to the immune system in numerous vaccine strategies. Particularly in HIV vaccine development efforts, two main viral ...
    • Article  

      HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 Δ32-negative female sex workers in Chiang Rai, northern Thailand 

      Sriwanthana, B.; Hodge, T.; Mastro, T. D.; Dezzutti, C. S.; Bond, K.; Stephens, H. A. F.; Kostrikis, Leontios G.; Limpakarnjanarat, K.; Young, N. L.; Qari, S. H.; Lal, R. B.; Chandanayingyong, D.; McNicholl, J. M. (2001)
      Understanding how highly HIV-exposed individuals remain HIV uninfected may be useful for HIV vaccine design and development of new HIV prevention strategies. To elucidate mechanisms associated with resistance to HIV ...
    • Article  

      A holo'ome approach in colon cancer: We change as we age 

      Apidianakis, Yiorgos; Eliopoulos, Aristides G. (2015)
    • Article  

      The homeobox transcription factor cut coordinates patterning and growth during drosophila airway remodeling 

      Pitsouli, Chrysoula; Perrimon, N. (2013)
      A fundamental question in developmental biology is how tissue growth and patterning are coordinately regulated to generate complex organs with characteristic shapes and sizes. We showed that in the developing primordium ...
    • Article  

      Homeostasis in Infected Epithelia: Stem Cells Take the Lead 

      Pitsouli, Chrysoula; Apidianakis, Yiorgos; Perrimon, N. (2009)
      To maintain tissue homeostasis and avoid disease, epithelial cells damaged by pathogens need to be readily replenished, and this is mainly achieved by the activation of stem cells. In this Short Review, we discuss recent ...