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Clinical trial design methodologies for advanced sarcoma therapy
(2015)
Sarcomas are rare and heterogeneous mesenchymal tumors affecting connective tissue. For many years, doxorubicin-based chemotherapy has been the main systemic therapy option for patients with metastatic soft tissue sarcoma. ...
Assessing response to chemotherapy in metastatic melanoma with FDG PET: Early experience
(2007)
The management of metastatic melanoma remains challenging with only modest response rates to chemotherapy but the need to identify the best re-staging techniques remains paramount. This study evaluates our early experience ...
Promising novel therapeutic approaches in the management of gastrointestinal stromal tumors
(2017)
Primary and secondary resistance to currently available licensed tyrosine kinase inhibitors poses a real clinical challenge in the management of advanced gastrointestinal stromal tumors. Within the frame of early phase ...
The role of digital breast tomosynthesis in breast cancer screening: a manufacturer- and metrics-specific analysis
(2019)
Aim Digital Breast Tomosynthesis (DBT), with or without Digital Mammography (DM) or Synthetic Mammography (SM), has been introduced or is under consideration for its introduction in breast cancer screening in several ...
Gastric collision tumors: An insight into their origin and clinical significance
(2015)
Collision tumors are rare neoplasms displaying two distinct cell populations developing in juxtaposition to one another without areas of intermingling. They are rare entities with only 63 cases described in English literature. ...
Role of palliative chemotherapy in advanced epithelioid sarcoma
(2012)
Background: Epithelioid sarcoma is a rare soft tissue sarcoma subtype. The response of this disease to chemotherapy is not well described. The aim of this study was to investigate the response rate and progression-free ...
Is there a case for anti-HER2 therapy without chemotherapy in early breast cancer?
(2011)
Summary: Trastuzumab in combination with chemotherapy is now standard of care for patients with early HER2-positive cancers larger than 1 cm. Some patients however may not need or simply may not want chemotherapy with its ...
Chemotherapy in clear cell sarcoma
(2011)
Clear cell sarcoma is a rare translocation-related sarcoma. There have been few studies documenting the response rate and progression-free survival in clear cell sarcoma patients treated with palliative chemotherapy. The ...