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Heterogeneity in cancer guidelines: Should we eradicate or tolerate?
(2008)
Background: Heterogeneity in aspects of development, structure and context of oncology guidelines was not evaluated. We analysed and critically examined its implications. Materials and methods: Nine cancer clinical practice ...
Oncology for medical students:. A European School of Oncology contribution to undergraduate cancer education
(2007)
Worldwide undergraduate cancer medicine is taught in a non-unanimous manner. There are frequent overlaps, omissions and discrepancies in the curricula of different medical schools concerning oncology teaching. Various ...
The missing kiss of life: Transcriptional activity of the metastasis suppressor gene KiSS1 in early breast cancer
(2007)
Background: KiSS-1 is a metastasis suppressor gene encoding a neuropeptide with potent antimetastatic activities in tumour cell lines. The transcriptional activity of the gene and its associations in resected breast cancer ...
Old habits die hard: Chest radiography for screening purposes in primary care
(2006)
Objective: To assess whether the use of chest radiography for screening changes over time. Design: Systematic review. Data Sources: MEDLINE, ISI, Cochrane Central Register of Controlled Trials, and handsearching of selected ...
Cancer of unknown primary patients with midline nodal distribution: Midway between poor and favourable prognosis?
(2011)
Background: Midline nodal cancer of unknown primary (CUP) has varying definitions and an unclear natural history compared to that of extragonadal germ cell cancer (EGCC) and neuroendocrine tumors. Methods: We systematically ...
Biweekly administration of 24-h infusion of irinotecan followed by a 1-h infusion of docetaxel: A phase I study
(2004)
We developed a chemotherapy combination regimen based on preclinical data suggesting synchronization of cancer cells in G2/M phase when exposed to irinotecan over a protracted period. This phase I study aimed to determine ...
The ESMO guideline strategy: An identity statement and reflections on improvement
(2015)
Guidelines should provide recommendations on the optimal management of a patient in specific clinical circumstances based on the scientific evidence. ESMO, as Europe's leading society in medical oncology produces a range ...
Prognostic significance of WNT and hedgehog pathway activation markers in cancer of unknown primary
(2015)
Background: Cancer of unknown primary (CUP) possesses distinct biology and peculiar natural history, in which the roles of the winged and hedgehog signalling pathways are unclear. Materials and methods: We constructed ...
Cancer of unknown primary site: Missing primary or missing biology?
(2007)
Cancer of unknown primary site (CUP) ranks as the fourth most common cause of cancer deaths and represents both a diagnostic and a management challenge. In CUP, the regression or dormancy of the primary tumor, the development ...