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The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host

dc.contributor.authorChristaki, Eirinien
dc.contributor.authorGiamarellos-Bourboulis, Evangelos J.en
dc.creatorChristaki, Eirinien
dc.creatorGiamarellos-Bourboulis, Evangelos J.en
dc.date.accessioned2018-06-22T09:52:49Z
dc.date.available2018-06-22T09:52:49Z
dc.date.issued2014
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41528
dc.description.abstractBacteremia develops when bacteria manage to escape the host immune mechanisms or when the otherwise well-orchestrated immune response fails to control bacterial spread due to inherent or acquired immune defects that are associated with susceptibility to infection.the pathogenesis of bacteremia has some characteristic features that are influenced by the genetic signature of the host.in this review, the host defense mechanisms that help prevent bacteremia will be described and the populations who are at risk because of congenital or acquired deficiencies in such mechanisms will be defined. A special mention will be made to novel insights regarding host immune defense against the most commonly isolated organisms from patients with community-acquired bloodstream infections. © 2014 Landes Bioscience.en
dc.language.isoengen
dc.sourceVirulenceen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectReviewen
dc.subjectUnindexed drugen
dc.subjectGamma interferonen
dc.subjectSepsisen
dc.subjectMeta analysis (topic)en
dc.subjectGenetic susceptibilityen
dc.subjectGenetic predisposition to diseaseen
dc.subjectPathogenesisen
dc.subjectReceptorsen
dc.subjectRisken
dc.subjectRandomized controlled trial (topic)en
dc.subjectC reactive proteinen
dc.subjectImmunoglobulin enhancer binding proteinen
dc.subjectInterleukin 1betaen
dc.subjectInterleukin 8en
dc.subjectLipid peroxidationen
dc.subjectNonhumanen
dc.subjectReactive oxygen metaboliteen
dc.subjectInterleukin 2en
dc.subjectAdaptive immunityen
dc.subjectApoptosisen
dc.subjectImmune responseen
dc.subjectImmunityen
dc.subjectInnateen
dc.subjectInnate immunityen
dc.subjectGeneticsen
dc.subjectSingle nucleotide polymorphismen
dc.subjectAnti-infective agentsen
dc.subjectAntigen presentationen
dc.subjectBacteremiaen
dc.subjectBacteriaen
dc.subjectBacterial clearanceen
dc.subjectBinding affinityen
dc.subjectBloodstream infectionen
dc.subjectCalgranulinen
dc.subjectCaspase recruitment domain protein 15en
dc.subjectCommunicable diseaseen
dc.subjectComplement component c1qen
dc.subjectComplement component c3en
dc.subjectComplement component c4b binding proteinen
dc.subjectComplement system proteinsen
dc.subjectGranulocyte chemotactic protein 2en
dc.subjectHost defenseen
dc.subjectHost-pathogen interactionsen
dc.subjectInflammasomeen
dc.subjectInterleukin 4en
dc.subjectLeukotriene b4en
dc.subjectLipopolysaccharideen
dc.subjectLiver functionen
dc.subjectMajor histocompatibility antigen class 1en
dc.subjectMajor histocompatibility antigen class 2en
dc.subjectMannose binding lectinen
dc.subjectMyeloid differentiation factor 88en
dc.subjectNeutrophilen
dc.subjectNeutrophil extracellular trapen
dc.subjectNucleotide binding oligomerization domain like receptoren
dc.subjectPattern recognitionen
dc.subjectPattern recognition receptoren
dc.subjectPeptidoglycanen
dc.subjectPhagocytosisen
dc.subjectRetinoic acid inducible protein ien
dc.subjectSkinen
dc.subjectSpleenen
dc.subjectToll like receptor 2en
dc.subjectToll like receptor 4en
dc.subjectTranscription factor nrf2en
dc.subjectTumor necrosis factor alphaen
dc.titleThe complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the hosten
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.4161/viru.26514
dc.description.volume5
dc.description.issue1
dc.description.startingpage57
dc.description.endingpage65
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidChristaki, Eirini [0000-0002-8152-6367]
dc.contributor.orcidGiamarellos-Bourboulis, Evangelos J. [0000-0003-4713-3911]
dc.gnosis.orcid0000-0002-8152-6367|0000-0003-4713-3911


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