Human peripheral blood and splenic T lymphocyte reactions versus kidney cortical cells
Date
1984Author
Roth, D.Kyriakides, George K.
Fuller, L.
Miller, Jody C.
Source
Transplantation proceedingsVolume
16Issue
6Pages
1532-1534Google Scholar check
Metadata
Show full item recordAbstract
These data suggest that a lymphoproliferative response to kidney-specific antigens might have been unmasked or amplified by the enzymatic digestion (collagenase, neuraminidase) used in deriving the KC cell population, a reaction not dependent on Ia antigens (at least as defined by L243 anti-DR antibody) as in the allogeneic response. The MLKC data obtained using infiltrating lymphocytes isolated from ESRD kidneys provokes questions regarding the contribution of T cell-mediated autoimmunity in the progression to chronic renal failure.