dc.contributor.author | Tsangaris, I. | en |
dc.contributor.author | Tsantes, Argirio E. | en |
dc.contributor.author | Bagos, Pantelis G. | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Kroupis, C. | en |
dc.contributor.author | Kopterides, Petros | en |
dc.contributor.author | Dimopoulou, Ioanna | en |
dc.contributor.author | Orfanos, S. | en |
dc.contributor.author | Kardoulaki, A. | en |
dc.contributor.author | Chideriotis, S. | en |
dc.contributor.author | Travlou, Anthi S. | en |
dc.contributor.author | Armaganidis, Apostolos | en |
dc.creator | Tsangaris, I. | en |
dc.creator | Tsantes, Argirio E. | en |
dc.creator | Bagos, Pantelis G. | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Kroupis, C. | en |
dc.creator | Kopterides, Petros | en |
dc.creator | Dimopoulou, Ioanna | en |
dc.creator | Orfanos, S. | en |
dc.creator | Kardoulaki, A. | en |
dc.creator | Chideriotis, S. | en |
dc.creator | Travlou, Anthi S. | en |
dc.creator | Armaganidis, Apostolos | en |
dc.date.accessioned | 2018-06-22T09:53:21Z | |
dc.date.available | 2018-06-22T09:53:21Z | |
dc.date.issued | 2009 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41796 | |
dc.description.abstract | Background: Several reports have shown that homocysteine promotes thrombosis by disturbing the procoagulant-anticoagulant balance, whereas alterations in coagulation and fibrinolysis have been suggested as important pathogenetic and prognostic determinants of mortality in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). The objective of the study was to evaluate the effect of plasma homocysteine levels on the outcomes of patients with ALI/ARDS. Methods: Sixty-nine consecutive ventilated patients with ALI/ARDS were studied. Blood samples were drawn within 3 days of clinical recognition of ARDS. Measurement of plasma homocysteine, vitamin B12, folate, creatinine, protein C and plasminogen-activator inhibitor-1 antigen levels, and genotyping of the methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms were carried out. The primary outcomes were 28- and 90-day mortality, whereas secondary outcomes included nonpulmonary organ failure-free days, liberation from mechanical ventilation up to day 28, and ventilator-free days during the 28 days after enrollment. Results: In the multivariable analysis, plasma homocysteine concentration adjusted for age, Acute Physiology and Chronic Health Evaluation II score, methylenetetrahydrofolate reductase C677T and A1298C polymorphisms, and levels of plasminogen-activator inhibitor-1 antigen, protein C, creatinine, vitamin B12, and folate was not found to affect significantly mortality at 28 and 90 days (P = 0.39 and P = 0.83, respectively), days without organ failure besides lungs (P = 0.38), the probability of being free from mechanical ventilation at day 28 (P = 0.63), and days without ventilation assistance (P = 0.73). CONCLUSION | en |
dc.language.iso | eng | en |
dc.source | American Journal of the Medical Sciences | en |
dc.subject | 5 | |
dc.subject | Article | en |
dc.subject | Adult | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Female | en |
dc.subject | Major clinical study | en |
dc.subject | Prognosis | en |
dc.subject | Time factors | en |
dc.subject | Outcome assessment | en |
dc.subject | Male | en |
dc.subject | Mortality | en |
dc.subject | Single nucleotide polymorphism | en |
dc.subject | Dna polymorphism | en |
dc.subject | Genotype | en |
dc.subject | Polymorphism | en |
dc.subject | Single nucleotide | en |
dc.subject | Blood | en |
dc.subject | Middle aged | en |
dc.subject | Metabolism | en |
dc.subject | Acute lung injury | en |
dc.subject | Protein blood level | en |
dc.subject | Creatinine | en |
dc.subject | Creatinine blood level | en |
dc.subject | Artificial ventilation | en |
dc.subject | Genetics | en |
dc.subject | Clinical evaluation | en |
dc.subject | Time | en |
dc.subject | Plasminogen activator inhibitor 1 | en |
dc.subject | Serpine1 protein | en |
dc.subject | 10 methylenetetrahydrofolate reductase (fadh2) | en |
dc.subject | Acute respiratory distress syndrome | en |
dc.subject | Adult respiratory distress syndrome | en |
dc.subject | Amino acid blood level | en |
dc.subject | Cyanocobalamin | en |
dc.subject | Enzymology | en |
dc.subject | Folic acid | en |
dc.subject | Homocysteine | en |
dc.subject | Methylenetetrahydrofolate reductase (nadph2) | en |
dc.subject | Mthfr a1298c polymorphism | en |
dc.subject | Mthfr c677t polymorphism | en |
dc.subject | Plasma homocysteine | en |
dc.subject | Protein c | en |
dc.subject | Respiratory distress syndrome | en |
dc.title | The effect of plasma homocysteine levels on clinical outcomes of patients with acute lung injury/acute respiratory distress syndrome | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1097/MAJ.0b013e3181b97c00 | |
dc.description.volume | 338 | |
dc.description.issue | 6 | |
dc.description.startingpage | 474 | |
dc.description.endingpage | 477 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Bagos, Pantelis G. [0000-0003-4935-2325] | |
dc.contributor.orcid | Kopterides, Petros [0000-0002-7682-4482] | |
dc.contributor.orcid | Armaganidis, Apostolos [0000-0002-6630-2648] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0003-4935-2325 | |
dc.gnosis.orcid | 0000-0002-7682-4482 | |
dc.gnosis.orcid | 0000-0002-6630-2648 | |