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Immunization of patients with sjögren's syndrome with pneumococcal polysaccharide vaccine

dc.contributor.authorKarsh, J.en
dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorSchiffman, G.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.creatorKarsh, J.en
dc.creatorPavlidis, Nicholasen
dc.creatorSchiffman, G.en
dc.creatorMoutsopoulos, H. M.en
dc.date.accessioned2018-06-22T09:53:46Z
dc.date.available2018-06-22T09:53:46Z
dc.date.issued1980
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42009
dc.description.abstractThirty‐two patients with Sjögren's syndrome were randomly selected to receive either multivalent pneumococcal polysaccharide vaccine or saline placebo in a double‐blind study. Among placebo treated patients, levels of antipneumococcal antibodies remained constant. Immunized patients developed significant elevations of antibody concentrations against all 12 capsular serotypes measured. Levels fell, but persisted above baseline, for 8 of the serotypes 6 months after immunization. During the 6‐month study no clinical or serologic evidence of disease exacerbation occurred in either group. We conclude that pneumococcal vaccine can be safely and successfully administered to patients with Sjögren's syndrome. Copyright © 1980 American College of Rheumatologyen
dc.language.isoengen
dc.sourceArthritis & Rheumatismen
dc.subjectArticleen
dc.subjectHumanen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectMajor clinical studyen
dc.subjectClinical trialen
dc.subjectRandomized controlled trialen
dc.subjectAntibodiesen
dc.subjectBacterialen
dc.subjectPlaceboen
dc.subjectSjoegren syndromeen
dc.subjectSjogren's syndromeen
dc.subjectMiddle ageen
dc.subjectClinical trialsen
dc.subjectClinical studyen
dc.subjectImmunologyen
dc.subjectStreptococcus pneumoniaeen
dc.subjectRespiratory systemen
dc.subjectIntramuscular drug administrationen
dc.subjectAntibody formationen
dc.subjectAntibody productionen
dc.subjectAntigen antibody reactionen
dc.subjectBacterial polysaccharideen
dc.subjectBacterial vaccineen
dc.subjectBacterial vaccinesen
dc.subjectBacterium antibodyen
dc.subjectDrug therapyen
dc.subjectImmunizationen
dc.subjectPneumococcal polysaccharide vaccineen
dc.subjectPneumococcus vaccineen
dc.subjectPolysaccharidesen
dc.subjectRespiratory tract infectionen
dc.subjectTherapyen
dc.titleImmunization of patients with sjögren's syndrome with pneumococcal polysaccharide vaccineen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1002/art.1780231111
dc.description.volume23
dc.description.issue11
dc.description.startingpage1294
dc.description.endingpage1298
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidMoutsopoulos, H. M. [0000-0003-3287-4821]
dc.gnosis.orcid0000-0002-2195-9961
dc.gnosis.orcid0000-0003-3287-4821


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