Gastrinoma associated with common bile duct obstruction and the ectopic production of ACTH
Date
1979Author
Kyriakides, George K.Silvis, S. E.
Ahmed, M.
Vennes, J. A.
Vogel, S. B.
Source
The American Journal of SurgeryVolume
137Issue
6Pages
800-802Google Scholar check
Metadata
Show full item recordAbstract
A case of adrenocortical hyperfunction due to ectopic production of ACTH by a gastrin-producing tumor of the pancreas is described. Cushing's syndrome preceded the appearance of the overt Zollinger-Ellison syndrome by 2 years and was treated by bilateral adrenalectomy. The Zollinger-Ellison syndrome was initially treated with cimetidine, which successfully reduced the secretion of gastric acid. Because the pancreatic gastrinoma continued to grow, causing obstruction of the common bile duct, biliary diversion and total gastrectomy were performed. There is evidence that the pancreatic gastrinoma was the source of the ectopic production of ACTH and possibly secretin. The role of Histamine-2 blocking agents as therapy in the Zollinger-Ellison syndrome is discussed. © 1979.