Laboratory Assessment of the Anticoagulant Activity of Dabigatran
Ημερομηνία
2015Συγγραφέας
Kyriakou, EliasIkonomidis, Ignatios
Stylos, D.
Bonovas, Stefanos
Papadakis, I.
Nikolopoulos, Georgios K.
Kokoris, Styliani
Kalantzis, Dimitrios
Economopoulou, Christine
Kopterides, Petros
Lekakis, John
Tsantes, Argirio E.
Source
Clinical and Applied Thrombosis/HemostasisVolume
21Issue
5Pages
434-445Google Scholar check
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Εμφάνιση πλήρους εγγραφήςΕπιτομή
Background: Our aim was to identify laboratory assays in order to assess the anticoagulant effects of dabigatran etexilate (DE). Methods: Twenty patients with nonvalvular atrial fibrillation treated on DE (110 mg per os twice daily) and 20 on acenocoumarol were studied. Conventional coagulation tests, endogenous thrombin potential (ETP), thromboelastometry (ROTEM), epinephrine-induced light transmission aggregometry (LTA), and Hemoclot Thrombin Inhibitors (HTI) were performed in all patients. Results: In ROTEM analysis, the lysis index at 60 minutes was significantly lower in patients receiving DE (P = .011). In LTA, patients on DE showed decreased aggregation compared to those on acenocoumarol, marginally insignificant (P = .068). Regarding ETP, acenocoumarol affected thrombin generation more than dabigatran (area under the curve [AUC], P < .001), while statistically significant associations were detected between dabigatran levels, as determined by the HTI assay, and almost all parameters of ETP assay (AUC, P < .001). Conclusion: The role of ETP in estimating anticoagulant activity of dabigatran possibly requires further research. © The Author(s) 2014.
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