HIV/HBV co-infection and rate of antiretroviral treatment change after highly active antiretroviral treatment initiation in a cohort of HIV-infected patients in Greece
Date
2010Author
Nikolopoulos, Georgios K.Paraskeva, D.
Hatzitheodorou, E.
Moschidis, Zissis
Sypsa, V.
Zavitsanos, X.
Kalapothaki, Victoria
Hatzakis, A.
Source
International Journal of STD and AIDSVolume
21Issue
10Pages
702-707Google Scholar check
Keyword(s):
Metadata
Show full item recordAbstract
The current study investigated the impact of human immunodeficiency virus (HIV)/hepatitis B virus (HBV) co-infection on the rate of change of antiretroviral drugs after the initiation of highly active antiretroviral treatment (HAART). The data on 1425 HIV-positive patients with recorded serology for hepatitis B surface antigen (HBsAg) were retrospectively analysed. The estimated rate of treatment change was slightly higher in the HBsAg-positive group (0.57 per year) compared with the HBsAg-negative group (0.50 per year). Although this difference was insignificant in multivariable modelling, the confidence intervals of the estimates barely included unity. Antiretroviral drug family, calendar period, prior exposure to antiretrovirals and the diagnosis of acquired immunodeficiency syndrome were independently associated with the number of drug alterations. A slight impact of co-infection on the frequency of treatment change after the beginning of HAART cannot be excluded. However, the paucity of studies on this issue necessitates the conduct of further research.
Collections
Cite as
Related items
Showing items related by title, author, creator and subject.
-
Article
Epidemiology of aids defining conditions in Greece
Masgala, Aikaterini; Nikolopoulos, Georgios K.; Tsantes, Argirio E.; Paraskeva, D. (2004)Objective: To examine the secular trends of all AIDS opportunistic infections to occur first (Ols) in Greece, by year, by gender and by mode of transmission. Methods: The study included all AIDS defining conditions reported ...
-
Article
Effect of hepatitis C virus on immunological and virological responses in HIV-infected patients initiating highly active antiretroviral therapy: A meta-analysis
Tsiara, Chrissa G.; Nikolopoulos, Georgios K.; Dimou, Niki L.; Bagos, Pantelis G.; Saroglou, G.; Velonakis, E.; Hatzakis, A. (2013)Co-infection of human immunodeficiency virus (HIV) with hepatitis C virus (HCV) is rather common. In the era of highly active antiretroviral therapy (HAART), viral hepatitis could result in adverse outcomes in HIV+ patients. ...
-
Article
Recent advances in the treatment of HIV/HBV and HIV/HCV co-infection
Masgala, Aikaterini; Bonovas, Stefanos; Nikolopoulos, Georgios K. (2012)Concurrent infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in patients positive for human immunodeficiency virus (HIV) is relatively common. The treatment of co-infected individuals is rather complex ...