Increased number of MicroRNA target sites in genes encoded in CNV regions. Evidence for an evolutionary genomic interaction
Date
2011Author
Felekkis, Kyriacos N.Voskarides, Konstantinos
Dweep, H.
Sticht, C.
Gretz, N.
Constantinou-Deltas, Constantinos D.
Source
Molecular biology and evolutionVolume
28Pages
2421-2424Google Scholar check
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Show full item recordAbstract
MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome analysis, we demonstrate that both the number of miRNAs that target genes found in CNV regions as well as the number of miRNA-binding sites are significantly higher than those of genes found in non-CNV regions. This suggests that miRNAs may have acted as equilibrators of gene expression during evolution in an attempt to regulate aberrant gene expression and to increase the tolerance to genome plasticity. © 2011 The Author.