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Increased number of MicroRNA target sites in genes encoded in CNV regions. Evidence for an evolutionary genomic interaction

dc.contributor.authorFelekkis, Kyriacos N.en
dc.contributor.authorVoskarides, Konstantinosen
dc.contributor.authorDweep, H.en
dc.contributor.authorSticht, C.en
dc.contributor.authorGretz, N.en
dc.contributor.authorConstantinou-Deltas, Constantinos D.en
dc.creatorFelekkis, Kyriacos N.en
dc.creatorVoskarides, Konstantinosen
dc.creatorDweep, H.en
dc.creatorSticht, C.en
dc.creatorGretz, N.en
dc.creatorConstantinou-Deltas, Constantinos D.en
dc.date.accessioned2019-11-04T12:50:33Z
dc.date.available2019-11-04T12:50:33Z
dc.date.issued2011
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53071
dc.description.abstractMicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome analysis, we demonstrate that both the number of miRNAs that target genes found in CNV regions as well as the number of miRNA-binding sites are significantly higher than those of genes found in non-CNV regions. This suggests that miRNAs may have acted as equilibrators of gene expression during evolution in an attempt to regulate aberrant gene expression and to increase the tolerance to genome plasticity. © 2011 The Author.en
dc.sourceMolecular biology and evolutionen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-80052150067&doi=10.1093%2fmolbev%2fmsr078&partnerID=40&md5=e665a6ec2ace862fc111355cf5f081e1
dc.subjectarticleen
dc.subjecthumanen
dc.subjectHumansen
dc.subjectComputational Biologyen
dc.subjectGene Expression Regulationen
dc.subjectnonhumanen
dc.subjectgene expressionen
dc.subjectmicroRNAen
dc.subjectgene targetingen
dc.subjectMicroRNAsen
dc.subjectmolecular biologyen
dc.subjectcomputer modelen
dc.subjectgene interactionen
dc.subjectEvolution, Molecularen
dc.subjectgenetic codeen
dc.subjectGenome, Humanen
dc.subjectbinding siteen
dc.subjectcopy number variationen
dc.subjectRNA bindingen
dc.subject3' Untranslated Regionsen
dc.subjectDatabases, Geneticen
dc.subjectDNA Copy Number Variationsen
dc.subjectmolecular evolutionen
dc.titleIncreased number of MicroRNA target sites in genes encoded in CNV regions. Evidence for an evolutionary genomic interactionen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1093/molbev/msr078
dc.description.volume28
dc.description.startingpage2421
dc.description.endingpage2424
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :25</p>en
dc.source.abbreviationMol.Biol.Evol.en
dc.contributor.orcidConstantinou-Deltas, Constantinos D. [0000-0001-5549-9169]
dc.gnosis.orcid0000-0001-5549-9169


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