A one-pot, two-step synthesis of 3-deazacanthin-4-ones via sequential Pd-catalyzed Suzuki-Miyaura and Cu-catalyzed Buchwald-Hartwig reactions
Ημερομηνία
2017Source
Tetrahedron lettersVolume
58Issue
27Pages
2661-2664Google Scholar check
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Εμφάνιση πλήρους εγγραφήςΕπιτομή
3-Deazacanthin-4-one and nine analogues, including the 8-aza analogue, were prepared rapidly and in high yields from 8-iodoquinolones and 2-chloro(het)arylboronic acids. The strategy involves construction of the central B ring via concomitant Pd-catalyzed Suzuki-Miyaura C[sbnd]C and Cu-catalyzed Buchwald-Hartwig C[sbnd]N coupling reactions. © 2017 Elsevier Ltd