Synthetic libraries of tyrosine-derived bacterial metabolites
Ημερομηνία
2008ISSN
0960-894XSource
Bioorganic and Medicinal Chemistry LettersVolume
18Issue
10Pages
3117-3121Google Scholar check
Keyword(s):
Metadata
Εμφάνιση πλήρους εγγραφήςΕπιτομή
The preparation of a collection of 131 small molecules, reminiscent of families of long chain N-acyl tyrosines, enamides and enol esters that have been isolated from heterologous expression of environmental DNA (eDNA) in Escherichia coli, is reported. The synthetic libraries of N-acyl tyrosines and their 3-keto counterparts were prepared via solid-phase routes, whereas the enamides and enol esters were synthesized in solution-phase. © 2007 Elsevier Ltd. All rights reserved.