Substitution chemistry of 3,5-dichloro-4H-1,2,6-thiadiazine 4,4-ketals[ONLINE]
| dc.contributor.author | Kalogirou, Andreas S. | en |
| dc.contributor.author | Koutentis, Panayiotis Andreas | en |
| dc.creator | Kalogirou, Andreas S. | en |
| dc.creator | Koutentis, Panayiotis Andreas | en |
| dc.date.accessioned | 2019-11-21T06:19:40Z | |
| dc.date.available | 2019-11-21T06:19:40Z | |
| dc.date.issued | 2016 | |
| dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55620 | |
| dc.source.uri | https://nls.ldls.org.uk/welcome.html?ark:/81055/vdc_100034090920.0x000025 | |
| dc.subject | Chemistry | en |
| dc.subject | Organic | en |
| dc.title | Substitution chemistry of 3,5-dichloro-4H-1,2,6-thiadiazine 4,4-ketals[ONLINE] | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
| dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
| dc.type.uhtype | Article | en |
| dc.description.notes | <p>ID: 1082 | en |
| dc.description.notes | In: Tetrahedron letters, Vol. 57, no. 30 ( 2016), p.3307-3310. | en |
| dc.description.notes | Summary: Graphical abstractHighlights•3,5-Dichloro-4H-1,2,6-thiadiazine 4,4-ketals undergo Pd-catalyzed C–C coupling at the C-3/5 positions.•Nucleophilic substitution at C-3/5 can occur with methoxide, phenoxide and pyrrolidine.•3,5-Diphenyl derivatives can be hydrolysed to 3,5-diphenyl-4H-1,2,6-thiadiazin-4-one.AbstractThe reactivity of 3,5-dichloro-4H-1,2,6-thiadiazine 4,4-ketals towards nucleophilic substitution or palladium-catalyzed C–C coupling at the C-3/5 positions led to seven new 3,5-disubstituted 4H-1,2,6-thiadiazine ethylene glycol 4,4-ketals and seven 3,5-disubstituted 4H-1,2,6-thiadiazine catechol 4,4-ketals in 83–98% yields. Furthermore, 3,5-diphenyl-4H-1,2,6-thiadiazine ethylene glycol and catechol 4,4-ketals were successfully hydrolysed in conc. H2SO4at 20 °C to afford 3,5-diphenyl-4H-1,2,6-thiadiazin-4-one in 74% and 89% yields.</p> | en |
| dc.contributor.orcid | Koutentis, Panayiotis Andreas [0000-0002-4652-7567] | |
| dc.contributor.orcid | Kalogirou, Andreas S. [0000-0002-5476-5805] | |
| dc.gnosis.orcid | 0000-0002-4652-7567 | |
| dc.gnosis.orcid | 0000-0002-5476-5805 |
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