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Silver mediated direct C-H arylation of 3-bromoisothiazole-5-carbonitrile

dc.contributor.authorKalogirou, Andreas S.en
dc.contributor.authorKoutentis, Panayiotis Andreasen
dc.creatorKalogirou, Andreas S.en
dc.creatorKoutentis, Panayiotis Andreasen
dc.date.accessioned2019-11-21T06:19:41Z
dc.date.available2019-11-21T06:19:41Z
dc.date.issued2014
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/55625
dc.description.abstractPalladium catalyzed direct C-H arylation of 3-bromoisothiazole-5-carbonitrile with aryl/hetaryl iodides in the presence of AgF gave 13 4-aryl/hetaryl-3-bromoisothiazole-5-carbonitriles. The scope of this arylation was investigated and explanations for the limitations proposed. 3-Bromoisothiazole-5-carboxamide was isolated as a side-product, and its formation was attributed to Ag+-catalyzed hydration of the C-5 nitrile. The analogous phenylation of 3-chloroisothiazole-5-carbonitrile and 3-bromoisothiazole-4-carboxamide gave 3-chloro-4-phenylisothiazole-5-carbonitrile and 3-bromo-5-phenylisothiazole-4-carboxamide in 83 and 64% yields, respectively. © 2014 Elsevier B.V. All rights reserved.en
dc.sourceTetrahedronen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84906965116&doi=10.1016%2fj.tet.2014.07.064&partnerID=40&md5=170d32d2b30391fa8a2451ed6d15f56a
dc.subjectunclassified drugen
dc.subjectArticleen
dc.subjecthydrationen
dc.subjectcovalent bonden
dc.subjectsynthesisen
dc.subjectchemical modificationen
dc.subjectarylationen
dc.subjectsilveren
dc.subject3 bromoisothiazole 5 carbonitrileen
dc.subjectcyanideen
dc.subjectIsothiazoles Heteroarenes Sulfur-nitrogen heterocycles C-H arylation Palladiumen
dc.subjectphenylationen
dc.titleSilver mediated direct C-H arylation of 3-bromoisothiazole-5-carbonitrileen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.tet.2014.07.064
dc.description.issue38
dc.description.startingpage6796
dc.description.endingpage6802
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :1</p>en
dc.source.abbreviationTetrahedronen
dc.contributor.orcidKoutentis, Panayiotis Andreas [0000-0002-4652-7567]
dc.contributor.orcidKalogirou, Andreas S. [0000-0002-5476-5805]
dc.gnosis.orcid0000-0002-4652-7567
dc.gnosis.orcid0000-0002-5476-5805


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