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Fast Screening of Whole Blood Samples and Pharmaceutical Compounds for Enantiorecognition of Free L‐T3, L‐T4, and D‐T4

dc.contributor.authorMitrofan, Grigorinaen
dc.contributor.authorStefan‐van Staden, Raluca‐Ioanaen
dc.contributor.authorComnea‐Stancu, Ionela Ralucaen
dc.contributor.authorvan Staden, Jacobus Fredericken
dc.contributor.authorBazylak, Grzegorz O.en
dc.contributor.authorKapnissi‐Christodoulou, Constantina P.en
dc.contributor.authorAboul‐Enein, Hassan Y.en
dc.creatorMitrofan, Grigorinaen
dc.creatorStefan‐van Staden, Raluca‐Ioanaen
dc.creatorComnea‐Stancu, Ionela Ralucaen
dc.creatorvan Staden, Jacobus Fredericken
dc.creatorBazylak, Grzegorz O.en
dc.creatorKapnissi‐Christodoulou, Constantina P.en
dc.creatorAboul‐Enein, Hassan Y.en
dc.date.accessioned2019-11-21T06:21:32Z
dc.date.available2019-11-21T06:21:32Z
dc.date.issued2015
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/55866
dc.source.urihttps://nls.ldls.org.uk/welcome.html?ark:/81055/vdc_100027668742.0x00001a
dc.subjectPharmaceutical chemistryen
dc.subjectChiralityen
dc.titleFast Screening of Whole Blood Samples and Pharmaceutical Compounds for Enantiorecognition of Free L‐T3, L‐T4, and D‐T4en
dc.typeinfo:eu-repo/semantics/article
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>ID: 1053en
dc.description.notesIn: Chirality, Vol. 27, no. 12 ( 2015), p.973-978.en
dc.description.notesSummary: AbstractA fast screening method of whole blood was proposed for enantiorecognition of free L‐T3,L‐T4, and D‐T4. Stochastic microsensors based on four inulins (IN, IQ, TEX, and HD) immobilized on diamond paste (DP) were used for recognition of free L‐T3,L‐T4, and D‐T4. For the enantiorecognition of free L‐T4and D‐T4in whole blood and pharmaceutical samples, the best microsensor was the one based on TEX/DP (wide linear concentration ranges, and low limits of quantification). The best limit of detection for the assay of free L‐T3(400 fmol/L) was recorded using the microsensors based on HD/DP, while for the assay of free L‐T4, and D‐T4 the best limit of determination (1 pmol/L) was recorded using the TX/DP‐based microsensor. For the enantiorecognition of free L‐T3in whole blood and pharmaceutical samples the best microsensor was the one based on HD/DP (the wider linear concentration range, and the lower limit of quantification – of pmol/L magnitude order). For the enantiorecognition of free L‐T3in whole blood and pharmaceutical samples the best microsensor was the one based on HD/DP (the wider linear concentration range, and the lower limit of quantification – of pmol/L magnitude order). Free L‐T3,L‐T4, and D‐T4were recovered with high reliabilities in whole blood samples (recoveries higher than 99.00%, with RSD values lower than 1.00%) and pharmaceutical samples (recoveries higher than 95.00% with RSD values lower than 1.00%).Chirality 27:973–978, 2015. © 2015 Wiley Periodicals, Inc.Abstract</p>en
dc.contributor.orcidKapnissi‐Christodoulou, Constantina P. [0000-0003-3755-1052]
dc.gnosis.orcid0000-0003-3755-1052


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