High throughput biological analysis using multi-bit magnetic digital planar tags
Date
2008Author
Hong, B.Jeong, J. -R
Llandro, J.
Hayward, T. J.
Ionescu, A.
Trypiniotis, Theodossis
Mitrelias, Thanos
Kopper, K. P.
Steinmuller, S. J.
Bland, J. A. C.
ISBN
978-0-7354-0547-9Source
AIP Conference ProceedingsBiomagnetism and Magnetic Biosystems Based on Molecular Recognition Processes
Volume
1025Pages
74-81Google Scholar check
Keyword(s):
Metadata
Show full item recordAbstract
We report a new magnetic labelling technology for high-throughput biomolecular identification and DNA sequencing. Planar multi-bit magnetic tags have been designed and fabricated, which comprise a magnetic barcode formed by an ensemble of micron-sized thin film Ni80Fe20 bars encapsulated in SU8. We show that by using a globally applied magnetic field and magneto-optical Kerr microscopy the magnetic elements in the multi-bit magnetic tags can be addressed individually and encoded/decoded remotely. The critical steps needed to show the feasibility of this technology are demonstrated, including fabrication, flow transport, remote writing and reading, and successful functionalization of the tags as verified by fluorescence detection. This approach is ideal for encoding information on tags in microfluidic flow or suspension, for such applications as labelling of chemical precursors during drug synthesis and combinatorial library-based high-throughput multiplexed bioassays. © 2008 American Institute of Physics.