Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Submit Date

Αποτελέσματα 1-20 από 39

    • Master Thesis  

      Development of a de novo Molecular Beacon-Based Real-Time RT-PCR Assay for the Detection and Discrimination of SARS-CoV-2 Variants of Concern 

      Aristokleous, Antonia (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12-16)
      The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in late 2019 and is the causative agent of the Coronavirus Disease 2019 (COVID-19). Since its emergence it has led to a global pandemic with devastating ...
    • Master Thesis  Open Access

      Investigating the role of Methyl CpG Binding proteins in Cervical Cancer 

      Patera, Eleftherios (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-12)
      DNA methylation (5mC) is one of the main epigenetic modifications that drive gene regulation. Methyl CpG binding proteins (MBDs) bind methylated DNA and recruit the nucleosome remodelling and deacetylase complex (Nurd) ...
    • Master Thesis  Open Access

      Gene therapies and their potential application in Type 1 Diabetes 

      Kyriakou, Mikaella K. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-14)
      Type 1 diabetes (T1D) is an autoimmune metabolic disorder, that arises due to autoimmune destruction of the β-cells in the islets of Langerhans in the pancreas. As a result, there is insufficient insulin production and ...
    • Master Thesis  Open Access

      Investigation of the role of cytoskeleton protein KATNAL2 in ribosomal gene transcription in mouse cells 

      Timotheou, Kyriaki M (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-23)
      The discovery that katanin-like cytoskeleton protein KATNAL2, in addition to its intracellular localization at MTs and sites associated with MTs (centrioles, cilia), also, unexpectedly, resides in the nucleolus, suggests ...
    • Master Thesis  Open Access

      Molecular pathways affected by HBx protein and their targeting for therapy of Hepatocellular carcinoma 

      Ketti, Stavriani A. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12-09)
      Hepatitis B virus (HBV) infection can cause several types of liver disease including acute hepatitis, chronic hepatitis, and liver cirrhosis. It is also considered a significant risk factor for Hepatocellular carcinoma ...
    • Master Thesis  

      Establishment of an N-terminal acetylation enzymatic assay to validate novel substrates and to identify inhibitors of NAA40 

      Kouma, Maria P. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-24)
      NAA40 (N-alpha acetyltransferase 40) is a member of the extended family of NATs (N-terminal acetyltransferases) which deposit acetyl groups on the N-terminal ends of proteins. NAA40 is a highly selective NAT, and its two ...
    • Master Thesis  Open Access

      Human immune responses upon SARS-CoV-2 infection- inflammation and cytokine storm 

      Syrimi, Andriani (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12)
      Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in December 2019 in the city of Wuhan, China, causing the COVID-19 pandemic of acute respiratory ...
    • Master Thesis  Open Access

      Novel molecular approaches to treat colorectal cancer 

      Argyrou, Christina (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-10)
      Colorectal cancer is found to be the third most common type of cancer which has raised cases and mortality rate, worldwide. Patients with colorectal cancer, depending on tumour stage, undergo surgery, followed by either ...
    • Master Thesis  Open Access

      The genetic basis of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in two Cypriot Families and the development of a robust PKD1 and PKD2 mutation screening test using amplicon-based Next-Generation Sequencing (NGS) 

      Petrou, Avgousta (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-06-11)
      Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary kidney diseases, with a frequency of 1 in 1000 people in the general population. This progressive disorder is mainly caused by ...
    • Master Thesis  Open Access

      Extracellular Regulated Kinase (ERK): A novel regulator in the development and function of cilia 

      Nikolaou, Chrystalla S. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-06-14)
      The role of cilia in biomedicine is becoming more and more recognized since defects in ciliary structure and function induce ciliopathies such as cystic kidney disease, neurological anomalies, obesity, blindness, and ...
    • Master Thesis  Open Access

      Quantifying the fragmentation levels of amphibian, reptile, and terrestrial mammal habitats inside and outside of Natura 2000 sites within the European Union 

      Economides, Sophia (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-25)
      Natural landscapes are constantly being modified and fragmented through a plethora of human activities, such as urbanisation and agriculture. Landscape fragmentation can have multiple negative effects on biodiversity. For ...
    • Master Thesis  Open Access

      The HPV16 E6 and E7 oncogenes modify Glutamine metabolism in Cervical Cancers 

      Andreou, Vasiliki (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-18)
      Metabolic reprogramming is an established hallmark of cancer. Malignant cells induce metabolic adjustments to meet their high energy demands and sustain rapid proliferation. These metabolic changes involve modifications ...
    • Master Thesis  Open Access

      Inhibition of Focal Adhesion Kinase as an anti-metastatic therapy 

      Dionysi, Eleni N. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-07)
      Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, has a physiological role in cell migration, cell survival, wound healing, and cell cycle progression, via both kinase-dependent and kinase-independent functions. ...
    • Master Thesis  Open Access

      The amyloid hypothesis of Alzheimer’s Disease and its current treatment 

      Komodromou, Artemis A. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2020-12-14)
      Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is the commonest cause of dementia in the elderly population worldwide. It is a multifactorial disorder, characterized by extracellular β-amyloid peptide ...
    • Master Thesis  Open Access

      Mechanical Cell Membrane stimulation using Magnetic Tweezers increases cell membrane stiffness through integrin dependent and independent mechanisms 

      Michanikou, Antonis (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12)
      Several cellular processes, such as proliferation, migration tissue morphogenesis and tissue regeneration, are closely regulated by the cells ability to sense their microenvironment and translate mechanical stimuli to ...
    • Master Thesis  Open Access

      The nexus between circRNA and prostate cancer from the complex interventions to treatment expectation 

      Alshikh Saleh, Ahmad (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-20)
      Circular RNAs (circRNAs) are a kind of RNA that results through a non-regular process known as alternative splicing. Because of their possible regulatory activities during gene expression, circRNAs have lately sparked ...
    • Master Thesis  Open Access

      Bacterial Species Antagonizing Pseudomonas aeruginosa Infection 

      Grivogiannis, Evangelos (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-27)
      Microbial species rarely exist in isolation in nature. Epithelial interfaces, such as the bilaterian intestine or the mammalian lung, harbour polymicrobial communities increasing infection complexity at these sites. We ...
    • Master Thesis  

      Investigating the role of N-alpha acetyltransferase 40 in the DNA Damage Response 

      Papa, Christina C. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-28)
      N-terminal acetylation (Nt-ac) is one of the most common, most abundant, and evolutionary conserved post-translational modifications (PTMs) found in eukaryotic cells. This modification is catalyzed by a family of enzymes ...
    • Master Thesis  Open Access

      Reproductive biology and growth of the alien Red Sea goatfish Parupeneus forsskali (Fourmanoir & Guézé, 1976) off the coast of Cyprus 

      Saemundsson, Sigurdur (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-15)
      Goatfish (family Mullidae) are of great commercial and economical importance around the world, including in the Mediterranean Sea, where six goatfish species have been recorded. Four of those species are alien to the ...
    • Master Thesis  Open Access

      Spatiotemporal vocal interactions in a ground-dwelling Neotropical passerine 

      Elia, Stavroula (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-11)
      In many species, communication involves an exchange of information between the sender and the receiver, by using different types of signals. Among the different types of communication, acoustic communication has been studied ...