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Modelling Glioblastoma Angiogenesis in Drosophila larvae
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-27)
Glioblastoma multiforme (GBM) is the most common malignant type of cancer of the Central Nervous System (CNS) and is characterized as highly angiogenic. Poor prognosis combined with short lifespan after diagnosis (⁓18 ...
Molecular mechanisms that Hepatitis B virus uses to induce Hepatocellular Carcinoma
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2020-12-07)
Hepatitis B is an infectious liver disease caused by the Hepatitis B virus (HBV). HBV is a small DNA virus that mainly affects hepatocytes, which are the main liver cells, and it has the ability to replicate by reverse ...
Recombinant Poliovirus a therapeutic agent for Cancer
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05)
Cancer is a leading cause of global mortality, and its burden is growing despite the availability of standard treatment methods. Genetically and Morphologically tumor cells differ from normal cells. However, cancers arise ...
Hypomethylation of Alu Elements in chronic lymphocytic leukemia
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-10)
CLL is a malignant disease characterized by the uncontrolled clonal proliferation of small, mature-appearing neoplastic dysfunctional CD5+ B lymphocytes in which is driven by changes in DNA methylation. Genetic alterations ...
The PINK1/Parkin-dependent mitophagy pathway and its role in Parkinson’s disease
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024)
Parkinson's disease is the second most prevalent neurodegenerative disease, surpassed only by Alzheimer’s disease. The disease is relentless, progressive, and incurable, and there is a great need to understand its causes ...
MicroRNAs in Alzheimer's Disease: A Comprehensive Analysis and Therapeutic Implications
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)
Alzheimer's disease (AD) remains an enigmatic challenge in the field of neurodegenerative
disorders, characterized by progressive cognitive decline and the accumulation of aberrant protein
aggregates in the brain. This ...
Novel therapeutic approaches targeting the molecular mechanisms governing SARS-CoV-2 infection
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing worldwide pandemic of Coronavirus Disease 2019 (COVID-19), which remains a public health concern despite the successful ...
Application of conservation genetics in conservation planning, with a special focus on the impacts of hybridization on birds and their conservation
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-06-01)
Biodiversity consists of all different live forms found in Earth. It is important to sustain it as it has several important aspects, such as maintaining ecosystems, helping with their proper functioning and it also plays ...
Mechanisms underlying Trastuzumab Resistance in HER2-positive (HER2+) Breast Cancer and potential therapeutic approaches
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)
HER2-positive (HER2+) breast cancer is characterized by overexpression of HER2 (Human Epidermal Growth Factor Receptor 2) protein on the surface of cells in the breast's ducts or lobes. HER2 overexpression creates an ...
EZH2: Role in breast cancer and potential therapeutic applications
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)
Human diseases, most notably cancer, are frequently associated with epigenetic dysregulation. Epigenetic modifications control gene function beyond the underlying sequence and are heritable but reversible alterations in ...