On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas
Date
2019Author
Mascheroni, PietroLópez Alfonso, Juan Carlos
Kalli, Maria
Stylianopoulos, Triantafyllos
Meyer-Hermann, Michael
Hatzikirou, Haralampos
ISSN
2072-6694Source
CancersVolume
11Issue
5Google Scholar check
Metadata
Show full item recordAbstract
Tumor microenvironment is a critical player in glioma progression, and novel therapies for its targeting have been recently proposed. In particular, stress-alleviation strategies act on the tumor by reducing its stiffness, decreasing solid stresses and improving blood perfusion. However, these microenvironmental changes trigger chemo–mechanically induced cellular phenotypic transitions whose impact on therapy outcomes is not completely understood. In this work we analyze the effects of mechanical compression on migration and proliferation of glioma cells. We derive a mathematical model of glioma progression focusing on cellular phenotypic plasticity. Our results reveal a trade-off between tumor infiltration and cellular content as a consequence of stress-alleviation approaches. We discuss how these novel findings increase the current understanding of glioma/microenvironment interactions and can contribute to new strategies for improved therapeutic outcomes.
Links
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562768/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562768/