The cortical excitability profile of patients with the G209A SNCA mutation versus patients with sporadic Parkinson's disease: A transcranial magnetic stimulation study
Ημερομηνία
2018Συγγραφέας
Kimiskidis, Vasilios K.Papayiannopoulos, Sotirios
Sotirakoglou, Kyriaki
Karakasis, Haralambos
Katsarou, Zoe
Kazis, Dimitrios A.
Papaliagkas, Vasileios
Gatzonis, Stylianos
Papadimitriou, Alexandros
Hadjigeorgiou, Georgios
Bostanjopoulou, Sevasti
ISSN
0987-7053Source
Neurophysiologie CliniqueVolume
48Issue
4Pages
203-206Google Scholar check
Metadata
Εμφάνιση πλήρους εγγραφήςΕπιτομή
Mutations in the α-synuclein gene are a rare cause of Parkinson's disease. We investigated, by single-pulse TMS, the cortical excitability profile of nine α-synuclein patients in comparison with 24 idiopathic PD patients, subdivided into “akinetic” (n=17) and “tremor-dominant” (n=7) subgroups. The comparative assessment of rest motor threshold, active MEP and Silent Period Input/Output curves indicated that the cortical excitability of α-Synuclein patients is similar to patients with the “akinetic” form of PD. Both groups of patients exhibited differences in excitatory and inhibitory brain circuits from “tremor-dominant” patients indicating that varying clinical phenotypes are associated with differential profiles of corticospinal excitability.