NUIG4: a biocompatible pcu metal-organic framework with an exceptional doxorubicin encapsulation capacity
Ημερομηνία
2022-03-02Συγγραφέας
Ahmed, AhmedEfthymiou, Constantinos G.
Sanii, Rana
Patyk-Kazmierczak, Ewa
Alsharabasy, Amir M.
Winterlich, Meghan
Kumar, Naveen
Sensharma, Debobroto
Tong, Wenming
Guerin, Sarah
Farras, Pau
Hudson, Sarah
Thompson, Damien
Zaworotko, Michael J.
Tasiopoulos, Anastasios J.
Papatriantafyllopoulou, Constantina
ISSN
2050-7518Εκδότης
Royal Society of ChemistryPlace of publication
Cambridge, UKSource
Journal of materials chemistry. BVolume
10Issue
9Pages
1378-1385Google Scholar check
Keyword(s):
Metadata
Εμφάνιση πλήρους εγγραφήςΕπιτομή
Metal-organic frameworks (MOFs) are promising multifunctional porous materials for biomedical and environmental applications. Here, we report synthesis and characterization of a new MOF based on the tetrahedral secondary building unit [Zn4O(CBAB)3]n (NUIG4), where CBABH2 = 4-((4-carboxybenzylidene)amino)benzoic acid. NUIG4 belongs to the family of MOFs with primitive cubic pcu topology, being a rare example with 4-fold interpenetration. The pore architecture enables unprecedentedly high doxorubicin (DOX) loading capacity (1955 mg DOX/g NUIG4) with pH-controlled release. Solid-state NMR and ab initio modeling confirmed formation of aromatic π-π stacking interactions between DOX and the framework. Preliminary cell-line experiments suggested a protective effect of NUIG4 on healthy HDF cells against DOX toxicity. NUIG4 also displays potential for adsorptive small-molecule gas separation, with a BET surface area of 1358 m2 g-1 and high selectivity of 2.75 for C2H2 over CO2.