Browsing by Author "Jones, Robin Lewis"
Now showing items 1-20 of 25
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Article
Advanced aggressive fibromatosis: Effective palliation with chemotherapy
Constantinidou, Anastasia; Jones, Robin Lewis; Scurr, Michelle R.; Al-Muderis, Omar; Judson, Ian Robert (2011)Background. Aggressive fibromatosis (AF) is a locally invasive proliferative disease. The mainstay of treatment is surgery. Chemotherapy may be considered in inoperable AF following failure of hormonal therapy and/or NSAIDs. ...
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Article
Advanced soft-tissue sarcoma and treatment options: Critical appraisal of trabectedin
Desar, Ingrid M. E.; Constantinidou, Anastasia; Kaal, Suzanne E. J.; Jones, Robin Lewis; Graaf, W. T. A. van der (2016)Soft-tissue sarcomas (STS) are a heterogeneous group of rare solid tumors of mesenchymal origin. This paper reviews the current status of systemic treatment in advanced and metastatic soft tissue sarcomas, with an emphasis ...
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Article
Beyond triple-negative breast cancer: The need to define new subtypes
Constantinidou, Anastasia; Jones, Robin Lewis; Reis-Filho, J. S. (2010)Advances in the systemic treatment of early breast cancer have led to significant improvements in survival for patients with hormone receptor- and/or HER2-positive disease. In recent years, interest has focused on tumors ...
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Article
Chemotherapy in clear cell sarcoma
Jones, Robin Lewis; Constantinidou, Anastasia; Thway, K.; Ashley, Sue; Scurr, Michelle R.; Al-Muderis, Omar; Fisher, Cyril; Antonescu, Cristina R.; D'Adamo, David R.; Keohan, Mary Louise; Maki, Robert G.; Judson, Ian Robert (2011)Clear cell sarcoma is a rare translocation-related sarcoma. There have been few studies documenting the response rate and progression-free survival in clear cell sarcoma patients treated with palliative chemotherapy. The ...
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Article
Clinical activity and tolerability of a 14-day infusional ifosfamide schedule in soft-tissue sarcoma
Martin-Liberal, Juan; Alam, Salma; Constantinidou, Anastasia; Fisher, Cyril; Khabra, Komel; Messiou, Christina; Olmos, David; Mitchell, Scott; Al-Muderis, Omar; Miah, Aisha; Linch, Mark; Jones, Robin Lewis; Scurr, Michelle R.; Judson, Ian Robert; Benson, Charlotte (2013)Background. Soft-tissue sarcomas (STS) are a heterogeneous group of diseases with lack of effective treatments in most cases. Previous data suggest that continuous infusional ifosfamide regimens might improve cytotoxicity ...
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Article
Clinical trial design methodologies for advanced sarcoma therapy
Petek, B. J.; Pollack, S. M.; Constantinidou, Anastasia; Jones, Robin Lewis (2015)Sarcomas are rare and heterogeneous mesenchymal tumors affecting connective tissue. For many years, doxorubicin-based chemotherapy has been the main systemic therapy option for patients with metastatic soft tissue sarcoma. ...
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Article
Conventional anthracycline-based chemotherapy has limited efficacy in solitary fibrous tumour
Constantinidou, Anastasia; Jones, Robin Lewis; Olmos, David; Thway, K.; Fisher, Cyril; Al-Muderis, Omar; Judson, Ian Robert (2012)
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Article
Diagnosis, prognosis, and management of leiomyosarcoma: Recognition of anatomic variants
Bathan, Andrew J.; Constantinidou, Anastasia; Pollack, S. M.; Jones, Robin Lewis (2013)PURPOSE OF REVIEW: The purpose of this review is to present the most recent advances in the diagnosis of the more common leiomyosarcoma (LMS) anatomic variants, potentially useful prognostic markers that have recently been ...
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Article
Early assessment of MCV to predict clinical outcome in patients with advanced gastrointestinal stromal tumors (GIST) receiving imatinib.
Constantinidou, Anastasia; Krikelis, Dimitrios; Olmos, David; Scurr, Michelle R.; Jones, Robin Lewis; Ashley, Sue; Judson, Ian Robert (2012)
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Article
The efficacy of caffeine-potentiated chemotherapy in clear cell sarcoma
Jones, Robin Lewis; Constantinidou, Anastasia (2013)
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Article
Epigenetic modulation in well differentiated (WD) and dedifferentiated (DD) liposarcoma (LPS): a novel therapeutic approach
Constantinidou, Anastasia; Selfe, J.; Khin, T.; Popov, S.; Missiaglia, E.; Aladowicz, E.; Al-Saadi, R.; Olmos, David; Jones, Robin Lewis; Strauss, D. C.; Hayes, Alison J.; Graaf, W. T. A. van der; Judson, Ian Robert; Shipley, J. (2016)
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Article
The evolution of systemic therapy in sarcoma
Constantinidou, Anastasia; Pollack, S. M.; Loggers, Elizabeth; Rodler, E.; Jones, Robin Lewis (2013)Approximately 50% of patients with localized soft tissue sarcomas will develop recurrent disease after complete surgical resection, requiring alternative means of treatment. Conventional chemotherapy comprising of doxorubicin ...
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Article
Management and outcome of metastatic clear cell sarcoma
Constantinidou, Anastasia; Pollack, S. M.; Jones, Robin Lewis (2014)
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Article
MDM2 inhibition in liposarcoma: A step in the right direction
Constantinidou, Anastasia; Pollack, S. M.; Jones, Robin Lewis (2012)
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Article
Molecular Classification of Breast Cancer
Jones, Robin Lewis; Constantinidou, Anastasia; Reis-Filho, J. S. (2012)This article reviews the conceptual and practical implications of the intrinsic subtype classification of breast cancers and the limitations of this approach. It presents the most extensively validated gene expression ...
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Book Chapter
Molecular subtypes and emerging therapeutic opportunities
Constantinidou, Anastasia; Jones, Robin Lewis; Reis-Filho, J. S. (Future Medicine Ltd., 2011)Triple-negative breast cancers comprise a heterogeneous group of tumors with varying prognosis, but the majority are of high histological grade and have a poor prognosis. Although there is considerable overlap between ...
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Book Chapter
Molecular subtypes and emerging therapeutic opportunities
Constantinidou, Anastasia; Jones, Robin Lewis; Reis-Filho, J. S. (Future Medicine, 2011)
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Article
Molecular subtypes of gastrointestinal stromal tumors and their prognostic and therapeutic implications
Szucs, Z.; Thway, K.; Fisher, Cyril; Bulusu, Ramesh; Constantinidou, Anastasia; Benson, Charlotte; Graaf, W. T. A. van der; Jones, Robin Lewis (2017)Gastrointestinal stromal tumors (GISTs) are composed of various molecular subtypes, with differing prognostic and predictive relevance. Previously, tumors lacking mutations in the KIT and PDGFRA genes have been designated ...
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Article
New drugs and clinical trial design in advanced sarcoma: Have we made any progress?
Constantinidou, Anastasia; Miah, Aisha; Pollack, S. M.; Jones, Robin Lewis (2013)
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Article
Pegylated liposomal doxorubicin, an effective, well-tolerated treatment for refractory aggressive fibromatosis
Constantinidou, Anastasia; Jones, Robin Lewis; Scurr, Michelle R.; Al-Muderis, Omar; Judson, Ian Robert (2009)Background: Aggressive fibromatosis (AF) or desmoid tumour is a monoclonal proliferation which is locally invasive but does not metastasize. If local treatment fails to control the disease, systemic treatment with ...