Browsing by Author "Stylianopoulos, Triantafyllos"
Now showing items 21-37 of 37
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Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma
Zhao, Yanxia; Cao, Jinghong; Melamed, Alexander; Worley, Michael; Gockley, Allison; Jones, Dennis; Nia, Hadi T.; Zhang, Yanling; Stylianopoulos, Triantafyllos; Kumar, Ashwin S.; Mpekris, Fotios; Datta, Meenal; Sun, Yao; Wu, Limeng; Gao, Xing; Yeku, Oladapo; Del Carmen, Marcela G.; Spriggs, David R.; Jain, Rakesh K.; Xu, Lei (2019)In ovarian cancer patients, tumor fibrosis and angiotensin-driven fibrogenic signaling have been shown to inversely correlate with survival. We sought to enhance drug delivery and therapeutic efficacy by remodeling the ...
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Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression
Kalli, Maria; Voutouri, Chrysovalantis; Minia, Angeliki; Pliaka, Vaia; Fotis, Christos; Alexopoulos, Leonidas G.; Stylianopoulos, Triantafyllos (2019)Mechanical compression is a common abnormality of brain tumors that has been shown to be responsible for the severe neurological defects of brain cancer patients representing a negative prognostic factor. Indeed, it is of ...
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NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression
Demetriadou, Christina; Pavlou, Demetria; Mpekris, Fotios; Achilleos, Charis; Stylianopoulos, Triantafyllos; Zaravinos, Apostolos; Papageorgis, Panagiotis; Kirmizis, Antonis (2019)N-alpha-acetyltransferase 40 (NAA40) catalyzes the transfer of an acetyl moiety to the alpha-amino group of serine 1 (S1) on histones H4 and H2A. Our previous studies linked NAA40 and its corresponding N-terminal acetylation ...
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NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression
Demetriadou, Christina; Pavlou, Demetria; Mpekris, Fotios; Achilleos, Charis; Stylianopoulos, Triantafyllos; Zaravinos, Apostolos; Papageorgis, Panagiotis; Kirmizis, Antonis (2019)N-alpha-acetyltransferase 40 (NAA40) catalyzes the transfer of an acetyl moiety to the alpha-amino group of serine 1 (S1) on histones H4 and H2A. Our previous studies linked NAA40 and its corresponding N-terminal acetylation ...
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On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas
Mascheroni, Pietro; López Alfonso, Juan Carlos; Kalli, Maria; Stylianopoulos, Triantafyllos; Meyer-Hermann, Michael; Hatzikirou, Haralampos (2019)Tumor microenvironment is a critical player in glioma progression, and novel therapies for its targeting have been recently proposed. In particular, stress-alleviation strategies act on the tumor by reducing its stiffness, ...
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Ras suppressor-1 (RSU-1) promotes cell invasion in aggressive glioma cells and inhibits it in non-aggressive cells through STAT6 phospho-regulation
Louca, Maria; Stylianou, Andreas; Minia, Angeliki; Pliaka, Vaia; Alexopoulos, Leonidas G.; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2019)Most gliomas are invasive tumors formed from glial cells and associated with high mortality rates. In this study, we characterized four glioma cell lines of varying degree of aggressiveness (H4, SW1088, A172 and U87-MG) ...
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Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside
Stylianopoulos, Triantafyllos; Munn, Lance L.; Jain, Rakesh K. (2018)Physical forces have a crucial role in tumor progression and cancer treatment. The application of principles of engineering and physical sciences to oncology has provided powerful insights into the mechanisms by which these ...
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Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy
Stylianopoulos, Triantafyllos; Munn, Lance L.; Jain, Rakesh K. (2018)A solid tumor is like an aberrant organ - comprised of cancer cells and a variety of host cells embedded in an extracellular matrix - nourished by blood vessels and drained by lymphatic vessels. In its journey from the ...
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A simplified approach for the determination of fitting constants in Oliver-Pharr method regarding biological samples
Kontomaris, S. V.; Stylianou, A.; Nikita, K. S.; Malamou, A.; Stylianopoulos, Triantafyllos (2019)The atomic force microscopy (AFM) nanoindentation regarding biological samples is a challenging procedure. Biological samples at the nanoscale can be considered as purely elastic materials under the condition that the ...
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Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration
Kalli, Maria; Papageorgis, Panagiotis; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2018)Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated ...
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Solid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cells
Kalli, Maria; Minia, Angeliki; Pliaka, Vaia; Fotis, Christos; Alexopoulos, Leonidas G.; Stylianopoulos, Triantafyllos (2019)Solid stress is a biomechanical abnormality of the tumor microenvironment that plays a crucial role in tumor progression. When it is applied to cancer cells, solid stress hinders their proliferation rate and promotes cancer ...
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Stress alleviation strategy in cancer treatment: Insights from a mathematical model
Mpekris, Fotios; Voutouri, Chrysovalantis; Papageorgis, Panagiotis; Stylianopoulos, Triantafyllos (2018)Tumors generate mechanical forces during growth and progression, which are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. Tumor vessels—while nourishing the tumor—are usually ...
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Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
Stylianopoulos, Triantafyllos; Economides, Eva Athena; Baish, J. W.; Fukumura, D.; Jain, R. K. (2015)Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...
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Towards patient-specific modeling of brain tumor growth and formation of secondary nodes guided by DTI-MRI
Angeli, Stelios; Emblem, Kyrre E.; Due-Tonnessen, Paulina; Stylianopoulos, Triantafyllos (2018)Previous studies to simulate brain tumor progression, often investigate either temporal changes in cancer cell density or the overall tissue-level growth of the tumor mass. Here, we developed a computational model to bridge ...
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Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner
Papageorgis, P.; Polydorou, Christiana; Mpekris, Fotios; Voutouri, Chrysovalantis; Agathokleous, Eliana A.; Kapnissi‐Christodoulou, Constantina P.; Stylianopoulos, Triantafyllos (2017)Accumulation of mechanical stresses during cancer progression can induce blood and lymphatic vessel compression, creating hypo-perfusion, hypoxia and interstitial hypertension which decrease the efficacy of chemo- and ...
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Transforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion
Stylianou, Andreas; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2018)Background Tumor microenvironment consists of the extracellular matrix (ECM), stromal cells, such as fibroblasts (FBs) and cancer associated fibroblasts (CAFs), and a myriad of soluble factors. In many tumor types, including ...
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Tuning the Mechanical Properties of BIEE-Crosslinked Semi-Interpenetrating, Double-Hydrophilic Hydrogels
Papaparaskeva, Georgia; Voutouri, Chrysovalantis; Gkretsi, Vasiliki; Achilleos, Mariliz; Safarik, Ivo; Pospiskova, Kristyna; Stylianopoulos, Triantafyllos; Krasia‐Christoforou, Theodora (2018)Double-hydrophilic, semi-interpenetrating (semi-IPN) hydrogels are synthesized by encapsulating hydrophilic polyvinylpyrrolidone (PVP) linear chains in structure-defined 1,2-bis-(2-iodoethoxy)ethane (BIEE)-crosslinked ...