Browsing by Subject "Cancer"

Now showing items 41-51 of 51

    • Doctoral Thesis  Open Access

      The role of innate immunity and stress signalling pathways in intestinal proliferation, endoreplication and tumorigenesis 

      Panagi, Myrofora P. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2020-05)
      Ο ανεξέλεγκτος κυτταρικός πολλαπλασιασμός και ο πολλαπλασιασμός του DNA που δεν συνοδεύεται από κυτταρική διαίρεση έχουν περιγραφεί εκτενώς στα καρκινικά κύτταρα. Δεδομένου ότι και τα δύο προαναφερθέντα φαινόμενα προκαλούνται ...
    • Article  

      Scaling rules for diffusive drug delivery in tumor and normal tissues 

      Baish, J. W.; Stylianopoulos, T.; Lanning, R. M.; Kamoun, W. S.; Fukumura, D.; Munn, L. L.; Jain, R. K. (2011)
      Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that ...
    • Article  

      Screening practice and misplaced priorities 

      Mauri, D.; Valachis, A.; Polyzos, N. P.; Cortinovis, I.; Karampoiki, V.; Loukidou, E.; Alevizaki, P.; Kamposioras, K.; Kouris, G.; Alexandropoulou, P.; Tsali, L.; Panou, C.; Stamatelopoulos, A.; Lakiotis, V.; Spiliopoulou, A.; Terzoudi, A.; Ioakimidou, A.; Karathanasi, I.; Bristianou, M.; Casazza, G.; Pavlidis, Nicholas (2009)
      Purpose: To estimate cancer screening coverage among a large sample of Greek individuals. Methods: 7012 adults from 30 Hellenic areas were surveyed. Tests included: faecal occult blood test, sigmoidoscopy, chest X-ray, ...
    • Article  

      Shared mechanisms in stemness and carcinogenesis: Lessons from oncogenic viruses 

      Iacovides, D.; Michael, S.; Achilleos, Charis; Strati, Katerina (2013)
      A rise in technologies for epigenetic reprogramming of cells to pluripotency, highlights the potential of understanding and manipulating cellular plasticity in unprecedented ways. Increasing evidence points to shared ...
    • Article  

      Simultaneous targeting of multiple opioid receptors: A strategy to improve side-effect profile 

      Dietis, Nikolas; Guerrini, R.; Calo, G.; Salvadori, S.; Rowbotham, D. J.; Lambert, D. G. (2009)
      Opioid receptors are currently classified as (mu: mOP), δ (delta: dOP), κ (kappa: kOP) with a fourth related non-classical opioid receptor for nociceptin/orphainin FQ, NOP. Morphine is the current gold standard analgesic ...
    • Article  

      Somatization is associated with physical health-related quality of life independent of anxiety and depression in cancer, glaucoma and rheumatological disorders 

      Hyphantis, T.; Tomenson, B.; Paika, V.; Almyroudi, A.; Pappa, C.; Tsifetaki, N.; Voulgari, P. V.; Drosos, Alexandros A.; Pavlidis, Nicholas; Creed, F. (2009)
      Purpose: To test the relative importance of anxiety, depression and somatization as correlates of physical health-related quality of life (HRQOL) in several chronic physical disorders. Methods: In a cross-sectional study ...
    • Article  

      Switching benchmarks in cancer of unknown primary: From autopsy to microarray 

      Pentheroudakis, George; Golfinopoulos, Vassilis; Pavlidis, Nicholas (2007)
      Introduction: Cancer of unknown primary (CUP) is associated with unknown biology and dismal prognosis. Information on the primary site of origin is scant and has never been analysed. We systematically reviewed all published ...
    • Article  

      Synergy between bacterial infection and genetic predisposition in intestinal dysplasia 

      Apidianakis, Yiorgos; Pitsouli, Chrysoula; Perrimon, N.; Rahme, L. (2009)
      Accumulating evidence suggests that hyperproliferating intestinal stem cells (SCs) and progenitors drive cancer initiation, maintenance, and metastasis. In addition, chronic inflammation and infection have been increasingly ...
    • Article  

      Systemic treatment-induced gastrointestinal toxicity: Incidence, clinical presentation and management 

      Boussios, Stergios; Pentheroudakis, George; Katsanos, K.; Pavlidis, Nicholas (2012)
      The toxicity of cancer chemotherapy is among the most important factors limiting its use. Clear delineation and communication of benefits and risks is an essential component of treatment decisions. Gastrointestinal toxicity ...
    • Article  

      The treatment of cancer in Greek antiquity 

      Karpozilos, A.; Pavlidis, Nicholas (2004)
      Literary sources provide considerable information on the existence of various malignant tumours in the classical period. Based on a close reading of the ancient Greek medical treatises, this paper traces the history of the ...
    • Article  

      Weekly docetaxel in minimally pretreated cancer patients: A dose- escalation study focused on feasibility and cumulative toxicity of long-term administration 

      Briassoulis, E. Ch; Karavasilis, V.; Anastasopoulos, D.; Tzamakou, E.; Fountzilas, George; Rammou, D.; Kostadima, Vasiliki; Pavlidis, Nicholas (1999)
      Background: Docetaxel is an agent with impressive clinical activity but a rather poor profile of toxicity when given every three weeks. Therefore, optimisation of its clinical use is highly warranted. This is a dose- ...