Browsing by Author "Constantinou, Andreas I."
Now showing items 21-40 of 87
-
Article
Effect of the calmodulin inhibitor trifluoperazine on phosphorylation of P-glycoprotein and topoisomerase II: Relationship to modulation of subcellular distribution, DNA damage and cytotoxicity of doxorubicin in multidrug resistant L1210 mouse leukemia cells
Ganapathi, R.; Kamath, N.; Constantinou, Andreas I.; Grabowski, D.; Ford, J.; Anderson, A. (1991)
-
Article
The effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D/PKCα
Tonetti, D. A.; Zhang, Y.; Zhao, H.; Lim, S. -B; Constantinou, Andreas I. (2007)Soy supplements are often consumed by women for alleviating menopausal symptoms or for the perceived protective effects against breast cancer. More concerning is the concurrent consumption of soy isoflavones with tamoxifen ...
-
Article
The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells
Constantinou, Andreas I.; Grdina, D.; Kiguchi, K.; Huberman, E. (1992)Treatment of human K-562-J leukemia cells for 1 h with the topoisomerase II-reactive drugs VP-16, VM-26, or mAMSA resulted in a dose-dependent inhibition of proliferation and in an increase in the percentage of cells ...
-
Conference Object
The effects of applying cell-suppression and perturbation to aggregated genetic data
Antoniades, Athos; Keane, J.; Aristodimou, Aristos; Philipou, Christa; Constantinou, Andreas I.; Georgousopoulos, Christos; Tozzi, Federica; Kyriacou, Kyriacos C.; Hadjisavvas, Andreas; Loizidou, Maria A.; Demetriou, Christiana A.; Pattichis, Constantinos S. (2012)The key test for confidence in any association discovered within the medical domain is replication testing. That is, the ability of the association to be detected in independent populations. At the same time, in order to ...
-
Article
Efficacy of garbanzo and soybean flour in suppression of aberrant crypt foci in the colons of CF-1 mice
Murillo, G.; Choi, J. K.; Pan, O.; Constantinou, Andreas I.; Mehta, R. G. (2004)Background: Epidemiological studies have reported a low incidence of colon cancer in countries with high legume consumption. Moreover, experimental studies have found that legumes, such as soybeans and pinto beans, have ...
-
Article
Equol enhances tamoxifen's anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells
Charalambous, Christina; Pitta, Chara A.; Constantinou, Andreas I. (2013)Background: Soy phytoestrogens, such as daidzein and its metabolite equol, have been proposed to be responsible for the low breast cancer rate in Asian women. Since the majority of estrogen receptor positive breast cancer ...
-
Article
Erratum: Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase (Nature Medicine 1, 260-266, (1995))
Gerhauser, C.; Mar, W.; Lee, S. K.; Suh, N.; Luo, Y.; Kosmeder, J.; Luyengi, L.; Fong, H. H. S.; Kinghorn, A. D.; Moriarty, R. M.; Mehta, R. G.; Constantinou, Andreas I.; Moon, R. C.; Pezzuto, J. M. (1995)
-
Article
Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms
Liu, J.; Burdette, J. E.; Xu, H.; Gu, C.; Van Breemen, R. B.; Bhat, K. P. L.; Booth, N.; Constantinou, Andreas I.; Pezzuto, J. M.; Fong, H. H. S.; Farnsworth, N. R.; Bolton, J. L. (2001)Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus ...
-
Article
Evidence that a metabolilte of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro
Pisha, E.; Lui, X.; Constantinou, Andreas I.; Bolton, J. L. (2001)Estrogen replacement therapy has been correlated with an increased risk of developing hormone-dependent cancers. 4-Hydroxyequilenin (4-OHEN) is a catechol metabolite of equilenin and equilin which are components of the ...
-
Article
Flavonoids as DNA topoisomerase antagonists and poisons: Structure-activity relationships
Constantinou, Andreas I.; Mehta, R.; Runyan, C.; Rao, K.; Vaughan, A.; Moon, R. (1995)Selected flavonoids were tested for their ability to inhibit the catalytic activity of DNA topoisomerase (topo) I and II. Myricetin, quercetin, fisetin, and morin were found to inhibit both enzymes, while phloretin, ...
-
Article
Genistein as an Inducer of Tumor Cell Differentiation: Possible Mechanisms of Action
Constantinou, Andreas I.; Huberman, E. (1995)Decreased activity of either topoisomerases or tyrosine kinases has been implicated in the differentiation of a number of cell types. It is therefore conceivable that genistein, because of its reported ability to inhibit ...
-
Article
Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells
Constantinou, Andreas I.; Kamath, N.; Murley, J. S. (1998)The aim of this study was to identify the molecular mechanism of action of the isoflavone, genistein. Genistein at 0.15 mM caused MCF-7 apoptotic cell death, which was accompanied by cell cycle delay in the G2/M phase. ...
-
Article
Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells
Salti, G. I.; Grewal, S.; Mehta, R. R.; Das Gupta, T. K.; Boddie, A. W., Jr.; Constantinou, Andreas I. (2000)The present study was undertaken to determine if (a) genistein induces topo II-mediated DNA damage in HT-29 colon cancer cells
-
Article
Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice
Constantinou, Andreas I.; Krygier, A. E.; Mehta, R. R. (1998)Results of recent studies in animal models of mammary carcinogenesis showed that the soybean isoflavone genistein is a chemopreventive agent. The objective of the present study was to determine whether soybean isoflavones ...
-
Article
Genistein-induced cell differentiation and protein-linked DNA strand breakage in human melanoma cells
Kiguchi, K.; Constantinou, Andreas I.; Huberman, E. (1990)
-
Article
Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosol
Odiatou, Elena M.; Skaltsounis, Alexios Leandros; Constantinou, Andreas I. (2013)The olive polyphenols oleuropein and hydroxytyrosol were reported recently to produce extracellular hydrogen peroxide (H2O2) under standard culture conditions. The precise factors responsible for this production and the ...
-
Article
In vitro antioxidant activity and phenolic content of Cedrus brevifolia bark
Cretu, E.; Salminen, J. -P; Karonen, M.; Miron, A.; Charalambous, Christina; Constantinou, Andreas I.; Aprotosoaie, A. C. (2014)A raw extract and four extractive fractions were obtained from Cedrus brevifolia (Cyprus cedar) bark. They were all studied regarding the phenolic content and profile using spectrophotometry and HPLC-DAD-ESI-MS. The ...
-
Article
In vitro study on the antioxidant activity of a polyphenol-rich extract from pinus brutia bark and its fractions
Cretu, E.; Karonen, M.; Salminen, J. -P; Mircea, C.; Trifan, A.; Charalambous, Christina; Constantinou, Andreas I.; Miron, A. (2013)A crude hydromethanolic extract from Pinus brutia bark and its fractions (diethyl ether, ethyl acetate, n-butanol, and aqueous fractions) were studied with regard to their phenolic content and antioxidant activities. The ...
-
Article
Induction of caspase-independent programmed cell death by vitamin E natural homologs and synthetic derivatives.
Constantinou, Constantina; Hyatt, John Anthony; Vraka, Panayiota S.; Papas, Andreas M.; Papas, Konstantinos A.; Neophytou, Christiana M.; Hadjivassiliou, V.; Constantinou, Andreas I. (2009)Current observations in the literature suggest that vitamin E may be a suitable candidate for cancer chemotherapy. To investigate this further, we examined the ability of the vitamin E natural homologs [alpha-, beta-, ...
-
Article
Induction of Differentiation and DNA Strand Breakage in Human HL-60 and K-562 Leukemia Cells by Genistein
Constantinou, Andreas I.; Kiguchi, K.; Huberman, E. (1990)Genistein, an in vitro inhibitor of topoisomerase II and tyrosine kinases, suppressed growth and induced differentiation in HL-205 cells, a clonal population of the human promyelocytic HL-60 leukemia cells, and in K-562-J ...