Browsing by Subject "Time Factors"

Now showing items 21-26 of 26

    • Article  

      Therapeutic monitoring of continuous infusion etoposide in small-cell lung cancer 

      Joel, S. P.; Ellis, Paul Anthony; O'Byrne, K.; Papamichael, Dimitri; Hall, M.; Penson, R.; Nicholls, S.; O'Donnell, C.; Constantinou, Andreas I.; Woodhull, J.; Nicholson, M.; Smith, I.; Talbot, D.; Slevin, M. (1996)
      Purpose: To investigate the feasibility of therapeutic monitoring of etoposide at different plasma concentrations of the drug, and the resulting pharmacodynamic effects of such an approach. Patients and Methods: Forty- ...
    • Article  

      Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging 

      Vakoc, B. J.; Lanning, R. M.; Tyrrell, J. A.; Padera, T. P.; Bartlett, L. A.; Stylianopoulos, T.; Munn, L. L.; Tearney, G. J.; Fukumura, D.; Jain, R. K.; Bouma, Brett E. (2009)
      Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous ...
    • Article  

      Time-scale analysis of motor unit action potentials 

      Pattichis, Constantinos S.; Pattichis, Marios S. (1999)
      Quantitative analysis in clinical electromyography (EMG) is very desirable because it allows a more standardized, sensitive and specific evaluation of the neurophysiological findings, especially for the assessment of ...
    • Article  

      Trophoblast-specific gene manipulation using lentivirus-based vectors 

      Georgiades, Pantelis; Cox, B.; Gertsenstein, M.; Chawengsaksophak, K.; Rossant, J. (2007)
      The trophoblast layers of the mammalian placenta carry out many complex functions required to pattern the developing embryo and maintain its growth and survival in the uterine environment. Genetic disruption of many gene ...
    • Article  

      Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy 

      Lewin, S. R.; Vesanen, M.; Kostrikis, Leontios G.; Hurley, A.; Duran, M.; Zhang, L.; Ho, David D.; Markowitz, M.; Gibson, U. E.; Heid, C. A. (1999)
      We have designed a novel, precise, and sensitive assay to measure unspliced (US) human immunodeficiency virus type 1 (HIV-1) mRNA in peripheral blood mononuclear cells of HIV-1-infected individuals by using real-time PCR ...
    • Article  

      Variable clinical presentation of an MUC1 mutation causing medullary cystic kidney disease type 1 

      Bleyer, A. J.; Kmoch, S.; Antignac, C.; Robins, V.; Kidd, K.; Kelsoe, J. R.; Hladik, G.; Klemmer, P.; Knohl, S. J.; Scheinman, S. J.; Vo, N.; Santi, A.; Harris, A.; Canaday, O.; Weller, N.; Hulick, P. J.; Vogel, K.; Rahbari-Oskoui, F. F.; Tuazon, J.; Constantinou-Deltas, Constantinos D.; Somers, D.; Megarbane, A.; Kimmel, P. L.; Sperati, C. J.; Orr-Urtreger, A.; Ben-Shachar, S.; Waugh, D. A.; Mcginn, S.; Bleyer Jr., A. J.; Hodaňová, K.; Vyletal, P.; Živná, M.; Hart, T. C.; Hart, P. S. (2014)
      Background and objectives The genetic cause of medullary cystic kidney disease type 1 was recently identified as a cytosine insertion in the variable number of tandem repeat region of MUC1 encoding mucoprotein-1 (MUC1), a ...