Browsing by Subject "mathematical model"
Now showing items 21-40 of 43
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Measurement of B-meson lifetimes using fully reconstructed B decays produced in pp̄ collisions at √s = 1.8 TeV
(2002)We present an improved measurement of b-meson lifetimes using fully reconstructed B-decays produced in pp̄ collisions at √s = 1.8 TeV, using 114 pb-1 of data collected at the Collider Detector at Fermilab. We obtain τ(B+) ...
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Measurement of the tt̄ production cross section in pp̄ collisions at √s=1:96 TeV using kinematic fitting of b-tagged lepton+jet events
(2005)We report a measurement of the tt̄ production cross section using the CDF II detector at the Fermilab Tevatron. The data consist of events with an energetic electron or muon, missing transverse energy, and three or more ...
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Microphase separation under constraints: A molecular thermodynamic theory for polyelectrolytic amphiphilic model networks in water
(2004)The aqueous aggregation behavior of covalent model networks comprising amphiphilic ABA triblock copolymers with hydrophilic ionic mid-blocks and hydrophobic non-ionic end-blocks was studied by formulating a molecular ...
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Model-based tumor growth dynamics and therapy response in a mouse model of de novo carcinogenesis
(2015)Tumorigenesis is a complex, multistep process that depends on numerous alterations within the cell and contribution from the surrounding stroma. The ability to model macroscopic tumor evolution with high fidelity may ...
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Multiscale biphasic modelling of peritumoural collagen microstructure: The effect of tumour growth on permeability and fluid flow
(2017)We present an in-silico model of avascular poroelastic tumour growth coupled with a multiscale biphasic description of the tumour–host environment. The model is specified to in-vitro data, facilitating biophysically realistic ...
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Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
(2012)The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic ...
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A novel simple QSAR model for the prediction of anti-HIV activity using multiple linear regression analysis
(2006)A quantitative-structure activity relationship was obtained by applying Multiple Linear Regression Analysis to a series of 80 1-[2-hydroxyethoxy-methyl] -6-(phenylthio) thymine (HEPT) derivatives with significant anti-HIV ...
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Remodeling of extracellular matrix due to solid stress accumulation during tumor growth
(2015)Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive ...
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Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors
(2014)Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibits their proliferation rate, induces apoptosis and enhances their invasive and metastatic potential. Additionally, compression ...
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Role of vascular normalization in benefit from metronomic chemotherapy
(2017)Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in ...
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Search for new physics in photon-lepton events in pp collisions at √s = 1.8 TeV
(2002)We present the results of a search in pp collisions at √s = 1.8 TeV for anomalous production of events containing a photon with large transverse energy and a lepton (e or μ) with large transverse energy, using 86 pb-1 of ...
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Search for single-top-quark production in pp̄ collisions at √s=1.8 TeV
(2002)We search for standard model single-top-quark production in the W-gluon fusion and W* channels using 106 pb-1 of data from pp̄ collisions at √s=1.8 TeV collected with the Collider Detector at Fermilab. We set an upper limit ...
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Self-control with spiking and non-spiking neural networks playing games
(2010)Self-control can be defined as choosing a large delayed reward over a small immediate reward, while precommitment is the making of a choice with the specific aim of denying oneself future choices. Humans recognise that ...
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The Solid Mechanics of Cancer and Strategies for Improved Therapy
(2017)Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...
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Spiking neural networks with different reinforcement learning (RL) schemes in a multiagent setting
(2010)This paper investigates the effectiveness of spiking agents when trained with reinforcement learning (RL) in a challenging multiagent task. In particular, it explores learning through rewardmodulated spike-timing dependent ...
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Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery
(2015)Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
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Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
(2015)Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...
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Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
(2015)Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...
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Transport of ellipsoid fibers in oscillatory shear flows: Implications for aerosol deposition in deep airways
(2018)It is widely acknowledged that inhaled fibers, e.g. air pollutants and anthropogenic particulate matter, hold the ability to deposit deep into the lungs reaching the distal pulmonary acinar airways as a result of their ...