Browsing by Author "Baish, J. W."
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Article
Role of vascular normalization in benefit from metronomic chemotherapy
Mpekris, F.; Baish, J. W.; Stylianopoulos, T.; Jain, R. K. (2017)Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in ...
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Article
Scaling rules for diffusive drug delivery in tumor and normal tissues
Baish, J. W.; Stylianopoulos, T.; Lanning, R. M.; Kamoun, W. S.; Fukumura, D.; Munn, L. L.; Jain, R. K. (2011)Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that ...
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Article
Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
Stylianopoulos, Triantafyllos; Economides, Eva Athena; Baish, J. W.; Fukumura, D.; Jain, R. K. (2015)Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...
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Article
Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
Stylianopoulos, T.; Economides, E. A.; Baish, J. W.; Fukumura, D.; Jain, R. K. (2015)Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...