Browsing by Author "Benson, Charlotte"

Now showing items 1-8 of 8

    • Article  

      Clinical activity and tolerability of a 14-day infusional ifosfamide schedule in soft-tissue sarcoma 

      Martin-Liberal, Juan; Alam, Salma; Constantinidou, Anastasia; Fisher, Cyril; Khabra, Komel; Messiou, Christina; Olmos, David; Mitchell, Scott; Al-Muderis, Omar; Miah, Aisha; Linch, Mark; Jones, Robin Lewis; Scurr, Michelle R.; Judson, Ian Robert; Benson, Charlotte (2013)
      Background. Soft-tissue sarcomas (STS) are a heterogeneous group of diseases with lack of effective treatments in most cases. Previous data suggest that continuous infusional ifosfamide regimens might improve cytotoxicity ...
    • Article  

      Gemcitabine Re-challenge in Metastatic Soft Tissue Sarcomas: A Therapeutic Option for Selected Patients 

      Constantinidou, Anastasia; Sebio, Ana; Benson, Charlotte; Antoniou, Georgios; Messiou, Christina; Miah, Aisha; Zaidi, Shane; Petruckevitch, Ann; Al-Muderis, Omar; Thway, Khin; VAN DER Graaf, Winette T.; Jones, Robin L. (2019)
      BACKGROUND/AIM: Treatment options for patients with metastatic soft tissue sarcomas are limited. Re-challenge with a previously successful gemcitabine-based regimen is common. There are no published data to support this ...
    • Article  

      Molecular subtypes of gastrointestinal stromal tumors and their prognostic and therapeutic implications 

      Szucs, Z.; Thway, K.; Fisher, Cyril; Bulusu, Ramesh; Constantinidou, Anastasia; Benson, Charlotte; Graaf, W. T. A. van der; Jones, Robin Lewis (2017)
      Gastrointestinal stromal tumors (GISTs) are composed of various molecular subtypes, with differing prognostic and predictive relevance. Previously, tumors lacking mutations in the KIT and PDGFRA genes have been designated ...
    • Article  

      Promising novel therapeutic approaches in the management of gastrointestinal stromal tumors 

      Szucs, Z.; Thway, K.; Fisher, Cyril; Bulusu, Ramesh; Constantinidou, Anastasia; Benson, Charlotte; Graaf, W. T. A. van der; Jones, Robin Lewis (2017)
      Primary and secondary resistance to currently available licensed tyrosine kinase inhibitors poses a real clinical challenge in the management of advanced gastrointestinal stromal tumors. Within the frame of early phase ...
    • Article  

      The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma 

      Constantinidou, Anastasia; Tong, Daniel; Engelmann, Bodil; Chamberlain, Florence; Thway, Khin; Fisher, Cyril; Hayes, Andrew; Fotiadis, Nicos; Messiou, Christina; Miah, Aisha B.; Zaidi, Shane H.; Benson, Charlotte; Graaf, Winette Van Der; Jones, Robin L. (2019)
      Background/Aim: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease. Patients and Methods: ...
    • Article  

      Successful Ifosfamide Rechallenge in Soft-Tissue Sarcoma 

      Noujaim, J.; Constantinidou, Anastasia; Messiou, Christina; Thway, K.; Miah, Aisha; Benson, Charlotte; Judson, Ian Robert; Jones, Robin Lewis (2015)
      OBJECTIVES
    • Article  

      Synovial Sarcoma of the Thyroid Gland, Diagnostic Pitfalls and Clinical Management 

      Constantinidou, Anastasia; Owen, Carina; Miah, Aisha B.; Thway, Khin; Fisher, Cyril; Benson, Charlotte; Zaidi, Shane; Messiou, Christina; VAN DER Graaf, Winette T. A.; Jones, Robin L. (2018)
      BACKGROUND/AIM: Synovial sarcoma is a soft tissue sarcoma that tends to affect young adults. There are few reports on primary synovial sarcoma of the thyroid and the aim of this study was to document the clinical and ...
    • Article  

      Trabectedin in advanced synovial sarcomas: A multicenter retrospective study from four European institutions and the Italian Rare Cancer Network 

      Sanfilippo, R.; Dileo, Palma; Blay, Jean-Yves; Constantinidou, Anastasia; Cesne, Axel Le; Benson, Charlotte; Vizzini, L.; Contu, Marianna; Baldi, Giacomo G.; P, Angelo Dei Tos; Casali, Paolo G. (2015)
      Treatment options for patients with metastatic synovial sarcoma are limited. Over recent years, trabectedin has emerged as an effective agent for patients with advanced soft tissue sarcomas resistant to anthracyclines and ...